DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn75F and Serpinb1b

DIOPT Version :9

Sequence 1:	NP_001036614.1	Gene:	Spn75F / 317912	FlyBaseID:	FBgn0052203	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	XP_038952280.1	Gene:	Serpinb1b / 306891	RGDID:	1560658	Length:	380	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	93/374 - (24%)
Similarity:	168/374 - (44%)	Gaps:	49/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FEINLTKQLSKGRLARNFVYSPIAIRQALGLLYL-SKDNVTDQQLESALQLTGLNQEEIISLFK- 84
            |.:.|...||:.....| ::||.:|..||.:::| :|.:.....|..|......:.|:|.|.|:
  Rat    11 FALELFHTLSESSPTGN-IFSPFSISSALAMVFLGAKGSSAPSSLRLAETFHFDSVEDIHSRFQS 74

  Fly    85 ---EAREKVAQEQFTMGNRIYLSPDYNASPNITQLSENL-GVEVKNMTFSGDQSAASEIKKWLNK 145
               |.|:..|.....:.||:|....||..|.....::.: |.::..:.|   |.|:.:.:|.:||
  Rat    75 LNAEMRKHGASHTLKVANRLYGEKTYNFLPEFLASTQKMYGADLAPVDF---QHASEDARKEINK 136

  Fly   146 WI-GKAGG---NLFGKNDISQTTQIVAVQGMSYSCVWKNRETALTNRTFTL-LRQNKKPFVYTTQ 205
            |: |:..|   .|.....::.||::|.|..:.:..:|  :|..||..|... .|.|||. ....:
  Rat   137 WVKGQTEGKIPELLAGGVVNSTTKLVLVNAIYFKGIW--QEKFLTRHTTDAPFRLNKKD-TKMVK 198

  Fly   206 MMYTEA--PMDFFNNDQVRGVMVPFKNSDMGMLVLLPR---------PRYSTQQILYSLDTILKI 259
            |||.:.  |..:..:.:.:.:.:|::..::.|::|||.         .:...|..|..|....|.
  Rat   199 MMYQKEKFPFGYIPDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLQKIEEQLTLEKLYEWTKH 263

  Fly   260 KLRRSKKTHLFLPKFKVSESVDLNMALKALGIQNLFTNTNAANFKQYNSFDADQNRVL--MTIDV 322
            :..:....|:.|||||:.||..||..|..||:|:||:::.|.......|.|...::::  ..::|
  Rat   264 ENLKEIDVHVNLPKFKIEESYILNSNLGRLGLQDLFSSSKADLSGMSESRDIFISKIVHKSFVEV 328

  Fly   323 GDDFDDR-------VVY---------VNRGFVFVVKDKSTIYMI--GRM 353
            .::..:.       |.|         |:..|:|.::...|..|:  ||:
  Rat   329 NEEGTEAAAATAGLVEYCLVSIEAFIVDHPFLFFIRHNPTANMLFFGRV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn75F	NP_001036614.1	SERPIN	21..353	CDD:294093	92/372 (25%)
Serpinb1b	XP_038952280.1	serpinB1_LEI	1..380	CDD:381028	93/374 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910