DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn75F and SERPIND1

DIOPT Version :9

Sequence 1:	NP_001036614.1	Gene:	Spn75F / 317912	FlyBaseID:	FBgn0052203	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	399	Identity:	92/399 - (23%)
Similarity:	164/399 - (41%)	Gaps:	91/399 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLKHSYAYNFEINLTKQLSKGRLARNFVYSPIAIRQALGLLYLSKDNVTDQQLESALQ----LTG 73
            :|...:|:|....|..|::   ...|...:|:.|..|:|::.|.....|.:|:.|.|.    :..
Human   128 ILNAKFAFNLYRVLKDQVN---TFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189

  Fly    74 LNQEEII---SLFKEAREKVAQEQF--TMG--NRIYLSPDYNASPNI----TQLSENLGVEVKNM 127
            .::.||.   :||::...::.:..|  |:.  |.:|:...:   |.:    |::.|....|.:..
Human   190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQF---PILLDFKTKVREYYFAEAQIA 251

  Fly   128 TFSGDQSAASEIKKWLNKWIGKAGGNLF--GKNDISQTTQIVAVQGMSYSCVWKNR-ETALT-NR 188
            .|| |.:..|:    .|..|.|....|.  ...:|...||::.:..:.:...|.|: ...:| |.
Human   252 DFS-DPAFISK----TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNH 311

  Fly   189 TFTLLRQNKKPFVYTTQMMYT----------EAPMDFFNNDQVRG----VMVPFKNSDMGMLVLL 239
            .|   |.|::. |....||.|          |...|....:.|.|    ::||.|.|.|..|...
Human   312 NF---RLNERE-VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQ 372

  Fly   240 PRPRYSTQQILYSLDTILKIKLRRSKKTHLFLPKFKVSESVDLNMALKALGIQNLF-TNTNAANF 303
            ..||.        ::...|....|:::  :.|||||:.::.:|..:||.:||:.|| .|.|.|..
Human   373 LTPRV--------VERWQKSMTNRTRE--VLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427

  Fly   304 KQYNSFDADQNRVLM-------TIDVGDD--------------FDDRVVY-VNRGFVFVVKDKST 346
                   :|| |:.:       ||.|.::              ...:|.: |:|.|:|::.:..|
Human   428 -------SDQ-RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRT 484

  Fly   347 --IYMIGRM 353
              :..:||:
Human   485 SCLLFMGRV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn75F	NP_001036614.1	SERPIN	21..353	CDD:294093	89/389 (23%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	92/399 (23%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910