Protein Alignment CG32201 and P4HA2

DIOPT Version :10

• Sequence 1: NP_730346.2
• Gene: CG32201 / 317911
• FlyBaseID: FBgn0052201
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 158/575 - (27%)
• Similarity: 255/575 - (44%)
• Gaps: 99/575 - (17%)

  Fly     1 MRKYHSLLPVLLGFAVLN-------SFVGCVEDI--EEKERYSSSTVGLLKLLKVEEKFTDNLLN 56
            |:.:.|.| ::..|.||:       :.:|.:.|:  .|||...|    |.:.:.|||.    .|:
Human     1 MKLWVSAL-LMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQS----LKEYILVEEA----KLS 56

  Fly    57 QVDQLGEKFEALRMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEG 121
            ::.....|.|||          ..:|..:...|:::|:||:.|::|.:.|.|...:...:....|
Human    57 KIKSWANKMEAL----------TSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAG 111

  Fly   122 NQSILVDLVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSM 186
            ..:.|....:..|.|.|.:.|...:.|::..|.|....:::|.|.|.:|...|:..|...||.|.
Human   112 FIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSA 176

  Fly   187 YQQSDYQTAAKWYRIACKRELENPEQLFI---QI----------LGDPSEHLHR--QYIKSLFKY 236
            |.:.||.....|.....| :|:..|:...   |:          |||    |||  :..:.|...
Human   177 YNEGDYYHTVLWMEQVLK-QLDAGEEATTTKSQVLDYLSYAVFQLGD----LHRALELTRRLLSL 236

  Fly   237 GSTTSEPSKSIEEAFIMVQASQEELDNIMSDLNE-----PQN------DVEVEKDLYQVKRSPSN 290
            ..:......::.   ...|..:||.:..:::..|     |:.      |...|:|:|
Human   237 DPSHERAGGNLR---YFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVY-------- 290

  Fly   291 CELGCRG-----LYRQKTNLVCRY-KSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELK 349
             |..|||     ..|::..|.||| .......|.:||.|.|:....|.:..|::|:.|.||..:|
Human   291 -ESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIK 354

  Fly   350 GQSMNMVNGYASQRNGTEIRD------TVVRYDWWSNTSLVRE-------RINQRIIDMTGFNFL 401
            ..:       ..:.....:||      ||..|. .|.:|.:.|       |:|:|:..:||....
Human   355 EIA-------KPKLARATVRDPKTGVLTVASYR-VSKSSWLEEDDDPVVARVNRRMQHITGLTVK 411

  Fly   402 KDEKLQIANYGLGTYFQPHFDYS-SDGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTV 465
            ..|.||:||||:|..::||||:| :|..:|......|:|:|:.|.|.|:|..|||||||::...:
Human   412 TAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAI 476

  Fly   466 FPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPCKS 520
            :|:||:.::|:||...|:.|.|:.|:.||||.|.:|...||.....|.|..||.|
Human   477 WPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..167	CDD:462433	29/130 (22%)
		P4Hc	341..507	CDD:214780	63/179 (35%)
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	35/148 (24%)
		BamD	159..>272	CDD:443281	25/120 (21%)
		TPR	207..240		8/36 (22%)
		P4Hc	346..519	CDD:214780	64/180 (36%)