DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32201 and CG34345

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	180/534 - (33%)
Similarity:	291/534 - (54%)	Gaps:	50/534 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRKYHSLLPVLLGFAVLNSFVGC-----VEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQ 60
            :|.:|.   :||.:.:|..|..|     ..|:.::..||:|...|.:|.::|..:.::|.|.|..
  Fly     3 LRSFHY---ILLNWILLFLFTVCKAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYVSF 64

  Fly    61 LGEKFEALRMYLSSV--GYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQ 123
            |.:|.:.||::::|:  .|..|:.  ::.:|||||:|:|.||||.|:|.||...|.|:   :||.
  Fly    65 LQQKIKTLRIFINSLTPNYLDHKV--DRYKYVSNPLNSFGLLRRAHQDWPKLIAYLKD---QGNI 124

  Fly   124 SILVD----LVKMVPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGN 184
            .:.::    |:...|:..||..|:.|:.|||..||||..|:|||::.|.|.:.:::..|.:|:.:
  Fly   125 KVDIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALAD 189

  Fly   185 SMYQQSDYQTAAKWYRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEE 249
            .||::|:::.||:|||||            :.:...|..::       .||:   .:...|.:|:
  Fly   190 YMYKRSEFRRAAEWYRIA------------LSVFTKPKNNI-------AFKF---YAPKRKELEK 232

  Fly   250 AFIMVQASQEELDNIMSDLNEPQNDVEVEKDLYQVKRSPSNCELGCRGLYRQKTNLVCRYKSTAN 314
            .|::.:..:..::|:...|.|...|........:.::||:..|.||:|.:.....|||||.||..
  Fly   233 MFVISRLQEGSVENLTDCLKELSQDPNNSLVHLRPRKSPTMIEQGCQGKFPPGPQLVCRYNSTTT 297

  Fly   315 TFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQS-----MNMVNGYASQRNGTEIRDTVVR 374
            .|:|:||||.||||.||.:.:||:|:|||||.:|...:     :.....|.:......:....|.
  Fly   298 PFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVT 362

  Fly   375 YDWWSNTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNITTLGDR 439
            .|  ....|.:..:| |:.|::|.:......|...|||||.|||.|.|| .|....|.:|..|||
  Fly   363 DD--DGGKLDKTLVN-RMADISGLDVGNTTTLARINYGLGGYFQEHSDY-MDIKLYPELTEEGDR 423

  Fly   440 LASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLT 504
            |.:.|||.::||.||.|:||...:.:.|:|||.|:|:|||::|.|::.:.|:|||.:.|.||.|.
  Fly   424 LMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLV 488

  Fly   505 KWVPMFPQMFSFPC 518
            |.:..:.|||..||
  Fly   489 KSMLNYEQMFKKPC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	50/134 (37%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	63/170 (37%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	50/134 (37%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	62/168 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461773
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910