DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32201 and p4ha3

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	526	Identity:	142/526 - (26%)
Similarity:	248/526 - (47%)	Gaps:	87/526 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVGYELHRSL-NEKVQYVSNPINAFS 98
            :|.:.:.:.:..|.|..|:|:..::...::.|.::.:.|.| ..||..: ||....::|||.||.
Zfish    26 TSMLSVNQAVSAERKLIDHLIIYIEHEAQRLEDIKRFFSRV-TSLHDGIYNEPSDPIANPIAAFK 89

  Fly    99 LLRRTHEDLPKWHEYFKEAIGEGNQSILVD----LVKMVPNDVDMLSAMHGIQRIEKIYDLKIDD 159
            |::|...:   |.........|.|..:|.:    :...:|...|:..|.||:.|::.:|:|.::.
Zfish    90 LVKRLKSE---WLNVVHSTEAEENIKVLREDYRRMESSLPKLEDLRGAAHGLMRLQDVYNLHVES 151

  Fly   160 LAQGVLQGVQYNV---QLTYRDLIA------MGNSMYQQSDYQTAAKWYRIACK--RELE-NPEQ 212
            |.:|..|.:...|   :|:..|:::      :|...|...||..:..|:..|.:  |..| :||.
Zfish   152 LVRGHFQQISDPVDFYKLSVSDMLSGDDCFLVGKVAYDLEDYYHSVLWFEEAVRLFRGTEWSPEN 216

  Fly   213 LFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQEELDNIMSDLNEPQN---- 273
              ...|.|..:||    ..|.||.|        :|..|   :..|:|.|      |::|.|
Zfish   217 --EGTLEDALDHL----AFSHFKTG--------NISHA---LSLSRELL------LHDPMNRRVH 258

  Fly   274 -DVE-VEKDLYQ----------VKRSPSNCELGCRGLYRQ-------------KTNLVCRYKSTA 313
             :|| .||.|.:          :|| |....|..|..|.|             ..:|.|.|.:..
Zfish   259 FNVEKYEKLLNENLPATSSGLTLKR-PDGIYLRTRNAYEQLCQTKGSQPKHFENPSLFCDYFTNG 322

  Fly   314 NTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSM-----NMVNGYASQRNGTEIRDTVV 373
            :..|.|.|::.|.|||.|::.::|..:..:|.:.::..:|     ::|   ||..|.......:.
Zfish   323 SPALFLQPIRREIISLQPYVVLFHGFVTQAEAKNIRKYAMPGLRRSVV---ASGMNQATAEYRIS 384

  Fly   374 RYDWWSNTS-LVRERINQRIIDMTGFNFLKD--EKLQIANYGLGTYFQPHFDY-SSDGFETPNIT 434
            :..|...:: .|..:::|||..:||.|....  |.||:.|||:|.:::||||: :||......:.
Zfish   385 KSAWLKESAHEVVGKLDQRITLVTGLNVQPPYAEYLQVVNYGIGGHYEPHFDHATSDSSPLYRLK 449

  Fly   435 TLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGD 499
            | |:|:|:|:.|.|.|..||:|.|...|.:|...:.:.|:|:|||.:|:.::.:||:.|||:.|:
Zfish   450 T-GNRVATIMIYLSPVQAGGSTAFIYANFSVPVVQNAALFWWNLHKNGQGNVDTLHAGCPVIVGN 513

  Fly   500 RWTLTK 505
            :|.:.|
Zfish   514 KWGMFK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	33/133 (25%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	55/174 (32%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	33/133 (25%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	54/172 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850