DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32201 and CG9698

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	144/547 - (26%)
Similarity:	245/547 - (44%)	Gaps:	70/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVGYE 78
            |.:.:..:..|..:|    :.||...:.|:...|:|...::...:....:|.:.|:..|.....|
  Fly    10 FLLFHQAIPSVSGVE----FFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENE 70

  Fly    79 LHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKM-----VPNDVD 138
            .:.:......|..:|||.:.|.:|...|..:.......:.||   ..|..|.|.     :|:..:
  Fly    71 RNEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGE---KPLTRLRKFRNRETMPDKKE 132

  Fly   139 MLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAKWYRIAC 203
            :..|:.|:.|::.:|.||..|||:|:|.||.|..||.....:.:.....:....:.|..|...|.
  Fly   133 LEGAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWLIEAN 197

  Fly   204 KREL--ENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAF---IMVQASQEE--- 260
            .|..  |..|||..|||             :|........|..:.:.:.:   |.:|::.||
  Fly   198 DRLTGGEKEEQLKPQIL-------------ALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAK 249

  Fly   261 ----LDNIMSD---LNEPQNDVEVEKDLYQVKRSPSNCE---------LGCRGLYR----QKTNL 305
                ..|.:|:   |||       .|.:.:....|...|         |.|.|.:|    ::.:|
  Fly   250 NYETFLNALSEKALLNE-------SKPILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKEQRHL 307

  Fly   306 VCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSMN-MVNGYASQRNGTEIR 369
            .|.|.:..:.||.:||||.||:..||.:.:||:|:|.|||..::..:.| ::....:..|.:.:.
  Fly   308 RCGYVTETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESVVS 372

  Fly   370 DTVVRYDWWS----NTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFD-YSSDGFE 429
            :  ||...::    ....|...|:||:.|||..|....|..|.||||:|.::..|.| :....|:
  Fly   373 N--VRTSQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFD 435

  Fly   430 TPNITT--LGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSV 492
            ...:::  :|:|:|::|||.|:|.|||.|.||::...:.|:|.:..:|.|||..|..|:|:.|..
  Fly   436 AGLVSSPEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGA 500

  Fly   493 CPVLNGDRWTLTKWVPMFPQMFSFPCK 519
            ||::.|.:|...:|:....|....||:
  Fly   501 CPIIAGSKWVQNRWIRENDQSDRRPCE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	31/133 (23%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	54/173 (31%)
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	31/133 (23%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	54/172 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461854
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910