DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32201 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	141/561 - (25%)
Similarity:	244/561 - (43%)	Gaps:	101/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YHSLLPVLLGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEAL 68
            |..:..:::...|.|.            .:.||...:..|.:|||:..:...:.|:...::.:..
  Fly     8 YIGIFQLIIWVGVANG------------EFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFY 60

  Fly    69 RMYLSSVGYELHRSLNEKVQ---YVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQ----SIL 126
            |.|:..:..| |.....:::   |:.:|::||.|::|...|   |.....|.|...|.    ...
  Fly    61 RRYVEQIKRE-HEWATSQLKLDDYLGHPLHAFRLIKRLVRD---WDSLIFEPILANNAREEFRAF 121

  Fly   127 VDLVKM---VPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQ 188
            |:::..   .|:..::..|:.|:.|::|:|:|...|||.|::.|:.|...|.:|:...:|..::.
  Fly   122 VEVLSRDLGYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFD 186

  Fly   189 QSDYQTAAKWYRIACKRELENPEQLFIQILGDPSEHLHR-QYIKSLFKYGSTT------------ 240
            ..:||.:.:|.::|           ||.:...|.|.... .|:..:.:|.|..
  Fly   187 LGEYQRSLEWLQVA-----------FILLRNSPREEKDADHYLSDIREYASMANFELGNPKKAAR 240

  Fly   241 -------SEPSKSIEEAFIMVQASQEELDNIMSDLNEPQNDVEVEKD--------LYQVKRSPSN 290
                   |:|:.|       .|.:|:.|::     ..|..:|:..|.        |.|.:|.|..
  Fly   241 LLSQILESQPTHS-------AQQTQKYLES-----RVPGKNVQETKPSWFSNYTRLCQGRRLPEE 293

  Fly   291 CELGCRGLYRQKTNLVCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIREL--KGQSM 353
                     |....|.|......:.:..||||::|.:.|||.:.:||.:|...:|..:  :....
  Fly   294 ---------RSGDPLRCYLDGKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKE 349

  Fly   354 NMVNGYASQRNGT-EIRD-TVVRYDWWSNTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTY 416
            .||....:...|. .:|| .|.:..|....|.|...:.:.|..::||:....|.:|:||||:|..
  Fly   350 EMVRSAVAGSGGEGTVRDLRVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQ 414

  Fly   417 FQPHFDYSS----DGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFN 477
            ::||.||..    ..||       |||:::.:||.|:|.|||.|||.::||.:.|.||:::.|.|
  Fly   415 YEPHPDYFEVNLPKNFE-------GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHN 472

  Fly   478 LHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPC 518
            ||.....|.|:||:.|||:.|.:.....|:....|.|..||
  Fly   473 LHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPC 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	33/138 (24%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	56/173 (32%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	33/138 (24%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	57/174 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461757
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910