DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32201 and CG31013

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	173/546 - (31%)
Similarity:	270/546 - (49%)	Gaps:	66/546 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YHSLLPVLLGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEAL 68
            :||.|  :||...|            ::.:|.|.|.::.||::|:|..|||.|..:.|.:|.|.:
  Fly    13 FHSTL--VLGHRPL------------EKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEII 63

  Fly    69 RMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKMV 133
            |..|..:..|..:.....:.|:|||:|.||::||.|:|...|.:|.::.:|.............:
  Fly    64 RSQLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYMEQPVGIWQLKAFYSWKDEL 128

  Fly   134 PNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAKW 198
            |.:.|:..|..||.||:..||||:.|...|.:.|.|||..::..|::::|..::.::....|.:|
  Fly   129 PTERDLWDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQW 193

  Fly   199 YRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQEELDN 263
            .:       |.|::|..::|..| .||..:.:.:|           :.:.||.|..|...|.|..
  Fly   194 LQ-------EVPQRLQEELLIQP-RHLPIKEVDAL-----------RLLAEAQIKDQNYSEALPL 239

  Fly   264 IMSDLNEPQNDVEV----EKDLYQVKRSPSNC---------------ELGCRGLYRQKTNLVCRY 309
            :.:.|....:|..|    :|....::..|...               :|.|.|.....|.|.|.|
  Fly   240 LHNCLKLQPHDARVLRLWKKTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGPLESSTRLHCFY 304

  Fly   310 KSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQ-SMNMVNGYASQRNGT--EIRDT 371
            ..|...||||||||.|:|.|||::.:|||||...||..|.|: :.||.|....:....  :.|..
  Fly   305 NFTTTPFLRLAPLKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRGR 369

  Fly   372 VVRYDWWSNTS-LVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNIT- 434
            ..:..|....| .:.:||.:||:|||||:....|..|:.|||:|.::..|.||..  |.:.|.|
  Fly   370 TAKGFWLKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFD--FASSNHTD 432

  Fly   435 -------TLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSV 492
                   .||||:|::|||.::|.|||||||.::...|.||.|:.::|:||..||..|.|:.|:.
  Fly   433 TRSRYSIDLGDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAA 497

  Fly   493 CPVLNGDRWTLTKWVPMFPQMFSFPC 518
            |||:.|.:|.:|:|:....|:|..||
  Fly   498 CPVIVGSKWVMTEWIREKRQIFIRPC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	43/128 (34%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	65/177 (37%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	43/128 (34%)
		TPR_11	178..248	CDD:290150	18/88 (20%)
		TPR repeat	211..246	CDD:276809	10/45 (22%)
		P4Hc	336..513	CDD:214780	66/178 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461780
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910