DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32201 and CG31524

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	163/544 - (29%)
Similarity:	263/544 - (48%)	Gaps:	59/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LPVL-LGFAV---LNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEAL 68
            :||| |.|.|   |:..:|.:|  ..:.|::.|.|.:..||.:|:.....|....::|..|...:
  Fly     1 MPVLKLLFVVIFFLSLSMGQIE--ATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTI 63

  Fly    69 RMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYF-KEAIGEGNQSILVDLVKM 132
            |..:..:..:|.:|   |.:...:..|.:|.:|....|...|.:|. |..|.:......:|.::|
  Fly    64 RWGIQQMREQLDKS---KKEQSFDLFNRYSFIRHMQADWLMWKQYLDKPVIRDELNYKQMDNLRM 125

  Fly   133 VPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAK 197
             |.::|:..|...|:|::..|.:..:|:|:|.|.||||..:|:..|.:|||..:..||.:..|.:
  Fly   126 -PQELDLFDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAEQ 189

  Fly   198 WYRIACK-RELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQ--- 258
            |.....| ::.:.|:...|.:.|.....|.|...|..|:        .::.|.|....||:.
  Fly   190 WILAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFE--------RRNEEGALKAYQAALKHS 246

  Fly   259 -------EELDNIMSDL----------NEPQNDVEVEKDLYQVKRSPSNCELGCRGLYRQKTNLV 306
                   :|..|:...:          .||.:|:| |.:|      |..|...|.| .|:...|.
  Fly   247 PHDLEIFQEYQNLKRRVLTLSPSEPIREEPNDDIE-EMEL------PPCCSGRCEG-PRKLNRLY 303

  Fly   307 CRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSMNMV--NGYASQRNGTEIR 369
            |.|......||||||:|.|.:|:|||:.:.|:::...|...::..|.|.:  :...:..|..||.
  Fly   304 CVYNCVTAPFLRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETVNAANEFEIA 368

  Fly   370 DTVVRYDWW--SNTSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYS---SDGFE 429
            ........|  |:.:....::.||:.:.||.:....|..|:.|||:|..|:.|||.|   .|.|.
  Fly   369 KFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHFDTSLADEDRFV 433

  Fly   430 TPNITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCP 494
            ...|    ||||:.|||.::|||||||.||.:|:||||:.|::|.|:|||.:|...:|::|:.||
  Fly   434 NGYI----DRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVRTMHTGCP 494

  Fly   495 VLNGDRWTLTKWVPMFPQMFSFPC 518
            |:.|.:|.::||:....|.|..||
  Fly   495 VIVGSKWVVSKWIDDKGQEFRRPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	31/129 (24%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	62/172 (36%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	31/129 (24%)
		TPR_11	215..>259	CDD:290150	9/51 (18%)
		TPR_2	216..249	CDD:285020	8/40 (20%)
		P4Hc	340..507	CDD:214780	62/170 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461779
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900