Protein Alignment CG32201 and P4HA3

DIOPT Version :10

• Sequence 1: NP_730346.2
• Gene: CG32201 / 317911
• FlyBaseID: FBgn0052201
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 107/548 - (19%)
• Similarity: 189/548 - (34%)
• Gaps: 154/548 - (28%)

  Fly   259 SVFMENVKELMYTRPVCSDEYSAKLHLQK-QFMSQIINHKDIEIPHLGVVEDRLKD------KKV 316
            |..:.::.:::   |..||..:.:....| .|||:.:..|.....:...|.....|      .::
Human   293 STILLHINDII---PALSDSVTQERRPPKLAFMSRGVGDKGSSSHNKPKVTGSTSDPGSRNRSEL 354

  Fly   317 FIVLDNIDQSIQLDAIAKESRWF------GHGSRIIITTQDRKLLK--------AHDGINHIYNV 367
            |..|:.  .|:.......::.|:      |:.|.::......|:.|        ...||...||
Human   355 FYTLNG--SSVDSQQSKSKNPWYIDEAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYN- 416

  Fly   368 NFPSAYEACQIFCMYAFGQKF------PKDGFE-ELAWEVAKLL-GGLPLGLRVMGSHFRGMSKH 424
               |.|....:||::||....      ||:..: |...|..:|| ..:...||:.|        :
Human   417 ---SCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYG--------Y 470

  Fly   425 EWINALPRLRTRLDANIQSILKFSYNALCEEDKDLFLYIACLFNNKRIEKVEEHLAEKSLNVKQG 489
            .....:.:||..|: .:::...|:     .|:||...::..||::  |.:||..|..:|
Human   471 VCATKIMKLRKILE-KVEAASGFT-----SEEKDPEEFLNILFHD--ILRVEPLLKIRS------ 521

  Fly   490 LHVLTEKSLISIEGGRIKMHNLLEQLGKEIVRHGLGHQPIREPGKRQFLVDTRDICELLTNDTGS 554
                        .|.:::..|.              :|...|..::   |....|.:||     .
Human   522 ------------AGQKVQDCNF--------------YQIFMEKNEK---VGVPTIQQLL-----E 552

  Fly   555 KSVIGIHFYSSELSSELNISERAFEGMPNLKFLRFYYRYGDESDKLY---LPQGLNYLSQKLKIL 616
            .|.|..:...:|..|.|.|.      ||         |:|.:. ||:   .|      |.:|.|.
Human   553 WSFINSNLKFAEAPSCLIIQ------MP---------RFGKDF-KLFKKIFP------SLELNIT 595

  Fly   617 E-WDHFPLTC-----MPSNFCTEYLVELNMRFSKLHKLWEGNRPLANLNWMYLNHS----KILKE 671
            : .:..|..|     :....|.|...:.::...|:.:..:......:|:...||||    .:.|:
Human   596 DLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCSTQVHLHPRRLNHSYHPVSLPKD 660

  Fly   672 LPDLS-----TATNLQELFLVKCSSLVELPSSI--GKATNLQKLYLNM----------------- 712
            |||..     ......|||.|.|.......:.:  ||..:....:.:|
Human   661 LPDWDWRHGCIPCQKMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNIPQVTP 725

  Fly   713 CTSLVE-LPSSIGNLHKLQKLTLNGCSK 739
            |..:.| |..|:.:||.|....:.||::
Human   726 CPEVGEYLKMSLEDLHSLDSRRIQGCAR 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..167	CDD:462433
		P4Hc	341..507	CDD:214780	37/181 (20%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433
		BepA	<188..289	CDD:443813
		P4Hc	356..>478	CDD:214780	26/135 (19%)