DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32201 and p4ha1

DIOPT Version :9

Sequence 1:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	149/557 - (26%)
Similarity:	250/557 - (44%)	Gaps:	79/557 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KYHSLLPVLLGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEA 67
            |.|.:||:|..|:..::            .:.:|...::.||..|:....:|.:.:....:|...
Frog     2 KIHLVLPLLGLFSCAHA------------DFFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQ 54

  Fly    68 LRMYLSSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKM 132
            ::.:...:.:....:..:...|:.:|:|||.|::|.:.:..|......:.|.:|..|.|....:.
Frog    55 IKKWADKLDHLTDTATKDPEGYLGHPVNAFKLMKRLNTEWVKLENLILKDISDGFISNLTIQRQY 119

  Fly   133 VPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAK 197
            .|||.|...|...:.|::..|:|..|.:::|.|.||::...||..|...:|.:.|..:||.....
Frog   120 FPNDEDQTGAAKALLRLQDTYNLDTDTISKGNLPGVKHKTSLTAEDCFDLGKTAYTDADYYHTEL 184

  Fly   198 WYRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQE--- 259
            |.           ||...|:.......|.:..:   ..|.|........:::|..:.:.|.|
Frog   185 WM-----------EQALSQLDAGEESSLDKVMV---LDYLSYAVYQQGDLDKALTLTKRSLELDP 235

  Fly   260 -------ELDNIMS-----DLNEPQNDVE-----------VEKDLYQVKRSPSNCELGCRG---- 297
                   .|.:|||     ..:.|....|           :||:.|         |..|||
Frog   236 EHQRGNGNLRHIMSKESNKSSSSPSEGAELRTRKGRPKDHLEKEKY---------EKLCRGEGVK 291

  Fly   298 -LYRQKTNLVCRY-KSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSMNMVNGYA 360
             ..|::..|.||| ....:..|.|:|.|.|:....|.:..||:::.|.||.::|..:...:....
Frog   292 MTSRRQKRLFCRYFDGKKDPLLILSPTKQEDEWDKPRIVRYHDIISDEEISKVKELAKPRLRRAT 356

  Fly   361 SQRNGTEIRDT----VVRYDWWSN-TSLVRERINQRIIDMTGFNFLKDEKLQIANYGLGTYFQPH 420
            .....|.:.:|    :.:..|.|. ...|..|:|:||..:||.:....|:||:||||:|..::||
Frog   357 ISNPITGVLETAQYRITKSAWLSGYEDPVVARLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPH 421

  Fly   421 FD----YSSDGFETPNITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFNLHDD 481
            ||    |..|.|:  .:.| |:|:|:.|||.|:|..||||||||:...|:|:||:.::|:||.:.
Frog   422 FDFLRKYEPDAFK--KLGT-GNRVATWLFYMSDVEAGGATVFPEVGAAVYPKKGTAVFWYNLLES 483

  Fly   482 GKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPC 518
            |:.|..:.|:.||||.|::|...||:....|.|..||
Frog   484 GEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	28/128 (22%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	64/174 (37%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	15/86 (17%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	65/175 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110