DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP82 and Nkd1

DIOPT Version :9

Sequence 1:	NP_572487.3	Gene:	PIP82 / 31791	FlyBaseID:	FBgn0024943	Length:	1195	Species:	Drosophila melanogaster
Sequence 2:	NP_081556.3	Gene:	Nkd1 / 93960	MGIID:	2135954	Length:	471	Species:	Mus musculus

Alignment Length:	451	Identity:	85/451 - (18%)
Similarity:	132/451 - (29%)	Gaps:	168/451 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SQPGTYRSAGSL---------DDDYYAPGSGDRASRPIS----PIKIPVVGALDDSSPSENGNVR 213
            |.|...|.||::         |....|.|..|....|:.    |.||..:|:.|:
Mouse    48 SGPRQLRLAGTVGRGTRELVGDTSREALGEEDEDDFPLEVALPPEKIDSLGSGDE---------- 102

  Fly   214 TTFTQRLQR----GYKSLSELRIKHIFAKQTTVRRDNIEVDRYVEQYEREL---------KSEKL 265
                :|::|    |..|..:|:.            :.::.|..||:..|:.         .:.|:
Mouse   103 ----KRMERLSEPGQASKKQLKF------------EELQCDVSVEEDSRQEWTFTLYDFDNNGKV 151

  Fly   266 ARERRDREIAENYDIKIKTLAGTRQNTFDDDDVEH------------------EQFERGKISHET 312
            .||.....:...|::.             |..|.|                  .|.:|..:.:.|
Mouse   152 TREDITSLLHTIYEVV-------------DSSVNHSPTSSKTLRVKLTVAPDGSQSKRSVLFNHT 203

  Fly   313 DESGMEATPPLPSRRKPGIAATRFAKVRKPPLEMEEEQQQAAAEESPQANPPPPPPPRPSSYKQL 377
            |   :::|.| .:..||......:.|.::.||..:.:...                .:|..|...
Mouse   204 D---LQSTRP-RADTKPAEELRGWEKKQRAPLRFQGDSHL----------------EQPDCYHHC 248

  Fly   378 L---INKLPHLPSLPNLPQFSRTKEETTKTAENADENNASRKLSIRQNIKRLRKSIKRPSKIKS- 438
            :   |.:..|...|..:              ||..........|:.|. ..|...|..|::.:|
Mouse   249 VDENIERRNHYLDLAGI--------------ENYTSQFGPGSPSVAQK-SELPPRISNPTRSRSH 298

  Fly   439 -KAAAPVPDSDEEEATPDGQKTKDAPTRSSTANLRARLSRFASTEQLQQRWR------KSFKVAK 496
             ..||.:|....:...|......|.|              ||...:||||.|      |.|  .:
Mouse   299 EPEAAHIPHRRPQGVDPGSFHLLDTP--------------FAKASELQQRLRGTQDGSKHF--VR 347

  Fly   497 EPEELETKAEGSATGGASGVLGG------------------LLVGSQLEKTLAKLNEKVHQ 539
            .|     ||:|...|...|..|.                  |.....|..|||.|..|.|:
Mouse   348 SP-----KAQGKNMGMGHGARGARSKPPLVPTTHTVSPSAHLATSPALLPTLAPLGHKKHK 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
PIP82	NP_572487.3	None
Nkd1	NP_081556.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..82	9/33 (27%)
		Interaction with DVL1, DVL2 and DVL3. /evidence=ECO:0000269\|PubMed:11356022	125..190	11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..314	9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..382	10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930