Protein Alignment PIP82 and NKD1

DIOPT Version :9

• Sequence 1: NP_572487.3
• Gene: PIP82 / 31791
• FlyBaseID: FBgn0024943
• Length: 1195
• Species: Drosophila melanogaster
• Sequence 2: NP_149110.1
• Gene: NKD1 / 85407
• HGNCID: 17045
• Length: 470
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 111/529 - (20%)
• Similarity: 173/529 - (32%)
• Gaps: 137/529 - (25%)

  Fly   243 RRDNIEVDRYV--EQYERELKSEKLARERRDREIAENYDIKIKTLAG--TRQNTFD--DDDVEHE 301
            ||::.|.|.:.  ..:.|:...|.:.|:|....::....:::....|  ||:...|  .|.:..|
Human    14 RRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIGRSTRELVGDVLRDTLSEE 78

  Fly   302 QFERGKISHETDESGMEATPPLPSRRKPGIAATRFAKVRKPPLEMEEEQQQAAAEESPQANPPPP 366
                     |.|:..:|..  ||..:..|:.:.            :|::.:..:|
Human    79 ---------EEDDFRLEVA--LPPEKTDGLGSG------------DEKKMERVSE---------- 110

  Fly   367 PPPRPSSYKQLLINKLPHLPSLPNLPQFSRTKEETTKTAENADENNASRKLSIRQ---------- 421
              |.|.|.|||   |...|....::.:.||  :|.|.|..:.|.|....:..|..
Human   111 --PCPGSKKQL---KFEELQCDVSMEEDSR--QEWTFTLYDFDNNGKVTREDITSLLHTIYEVVD 168

  Fly   422 --------NIKRLR-KSIKRPSKIKSKAAAPVPDSDEEEATPDGQKTKDAPTRSSTANLRARLSR 477
                    :.|.|| |....|...:||.:..|..:|.:.|.|..:.......||.....||.| |
Human   169 SSVNHSPTSSKMLRVKLTVAPDGSQSKRSVLVNQADLQSARPRAETKPTEDLRSWEKKQRAPL-R 232

  Fly   478 FASTEQLQQRWRKSFKVAKEPEELETKAEGSATGGASGVLGGLLVGSQLEKTLAKLNEKVHQLKF 542
            |....:|:|.......|   .|.:|.:.......|..........||          ..|.|...
Human   233 FQGDSRLEQSGCYHHCV---DENIERRNHYLDLAGIENYTSQFGPGS----------PSVAQKSE 284

  Fly   543 FQRNANNQNATTSKQPKPNTVGH-EPIEIDDDELEATYHRSDSLEAENGNGNENDDSGEDISAEE 606
            .....:|...:.|.:|:...:.| :|..:|    .|::|..|:
Human   285 LPPRTSNPTRSRSHEPEAIHIPHRKPQGVD----PASFHFLDT---------------------- 323

  Fly   607 AFGQIQEEDNEEDHSQDQTK------RGQSSVSGIA-TAHAARQMAKLA-EIQAASKSGAAAWSS 663
            ...::.|.......:||.:|      :.|....|:. .|..||....|. .|.|.|.|...|.|.
Human   324 PIAKVSELQQRLRGTQDGSKHFVRSPKAQGKSVGVGHVARGARNKPPLGPAIPAVSPSAHLAASP 388

  Fly   664 ESLEEIADEDYPRVLIHQEHSD-AYEST-----LIIAVASKGSSMSPVVRSSGLKSSPA------ 716
            ..|..:|.      |.|::|.. |.||.     |...:||.|    ||:....|:..||
Human   389 ALLPSLAP------LGHKKHKHRAKESQQGCRGLQAPLASGG----PVLGREHLRELPALVVYES 443

  Fly   717 -AGPKTSPH 724
             ||.....|
Human   444 QAGQPVQRH 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP82	NP_572487.3	None
NKD1	NP_149110.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..114		5/47 (11%)
		Interaction with DVL1, DVL2 and DVL3. /evidence=ECO:0000250	125..190		12/66 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	192..228		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..314		9/52 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..357		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..470		2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930