Protein Alignment PIP82 and dpy-22

DIOPT Version :9

• Sequence 1: NP_572487.3
• Gene: PIP82 / 31791
• FlyBaseID: FBgn0024943
• Length: 1195
• Species: Drosophila melanogaster
• Sequence 2: NP_509645.1
• Gene: dpy-22 / 181194
• WormBaseID: WBGene00001081
• Length: 3498
• Species: Caenorhabditis elegans
• Alignment Length: 1168
• Identity: 200/1168 - (17%)
• Similarity: 355/1168 - (30%)
• Gaps: 400/1168 - (34%)

  Fly   201 LDDSSPSEN---GNVRTTFTQRLQRGYKSLSELRIKHIFAKQTTVRRDNIEVDRYV--------- 253
            :|..|.:::   |::|..:.|     |..|.:...|.:..:.|...|:::.  |::
 Worm  2020 VDGDSMNQHDRYGSIRVRWPQ-----YAGLMKKIRKEMQERFTDQTRNSLH--RFLPIGKMQMST 2077

  Fly   254 ---EQYERELK-SEKLARERRDREIAENYDIKIKTLAGTRQNTFDDDDVEHEQFERG-------- 306
               ::|::..| ::|::::....|..:|...........:.|.|:..|...:...:|
 Worm  2078 ISYKKYQKRPKVNQKMSKKFLAGEGLKNGKYSFLPEEKAKTNAFEHTDHLGDLIVKGGWKFRMFQ 2142

  Fly   307 -----KISHETD---ESGMEATPPLPSRR----------------KPGIAATRFAKVRKPPLEME 347
                 |::....   .|.|..|..|...|                .|.|..|:.  :.:|...::
 Worm  2143 TTRLDKVAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLAPPDIEITKI--IEQPVPVID 2205

  Fly   348 EEQQQAAAEESPQANPPPPPPPRPSSYKQLLINKLPHLPSLPNLPQFSRTKEETTKTAENADENN 412
            ||:.:..|||..:|                                 :..|||:....:..::||
 Worm  2206 EEEAKKRAEEEKEA---------------------------------AEKKEESKNAEDEKNKNN 2237

  Fly   413 ASRKLSIRQNIKRLRKSIKRPSKIKSKAAAPVPDSDEEEATPDGQKTKDAPTRSSTANLRARLSR 477
            |..|           |..|...|.|||         ::|...:.:|.|||..:....:.:..|.:
 Worm  2238 AENK-----------KDTKEGEKGKSK---------DKEKDGEKEKCKDASKKDDVTSEKNELEK 2282

  Fly   478 FAS-----------TEQLQQRWRKSFKVAKEPEELETKAEGSATGGASGVLGGLLVGSQLEKTLA 531
            .||           .:.:.....|...|.:.|   .|:..|......||..||   |.:.::.
 Worm  2283 RASDAAAATNAPETNKDMDTSTPKPAPVTRSP---ATRGRGGGRKRNSGARGG---GPRAKRA-- 2339

  Fly   532 KLNEKVHQLKFFQRNANNQNATTSKQPKPNTVGHEPIEIDDDELEATYHRSDSLEAENGN----- 591
                             |..|.|::.....|..:.||            .:.|..|..||
 Worm  2340 -----------------NSRADTAQAAAATTQWNAPI------------ANTSNPAAGGNFHAAM 2375

  Fly   592 -GNENDDSGEDISAEEAFGQIQEEDNEEDHSQDQTKRGQSSVSGIATAHAARQMAKLAEIQAASK 655
             ||:...|..  |::|....|:...|.:...:..:....|:.:..|.::|....:.:........
 Worm  2376 RGNQPPMSNG--SSDETKVHIRNLLNRKKEEKRNSLADASAAAAAANSNAMGNTSSMPPSGPPMP 2438

  Fly   656 SGAAAWSSESLEEIADEDYPRVLIHQEHSDAYESTLIIAVASKGSSMSPVVRSSGLKSSPAAGPK 720
            .|::..|:.:.:::..        .|:|             ..|.|||.:.::.|
 Worm  2439 MGSSMQSAGATQQLQG--------MQKH-------------QMGGSMSGMNQNMG---------- 2472

  Fly   721 TSPHPEIRISASGPQKSMS------YSPGNPRGEPVTKRSPSPEFKTPAGGNKIVPKSETSAWLP 779
                        |..:|||      ||..|....|:..:...|.|..|..|    |.:.:|..:.
 Worm  2473 ------------GMNQSMSHQAPPPYSSTNEMNRPLMNQYGGPHFAAPNPG----PLNRSSGPVS 2521

  Fly   780 NE------------------QIIAGFKEQTSWPAPA-----------------------LYKPKS 803
            :|                  |::...|::.:....|                       |.:.::
 Worm  2522 SETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERMQREAYMKEQQLLERKRA 2586

  Fly   804 ID----IFEASAGGSAAFADFDEALRNA------------PVLRISAGSSIDTSGEEADDSCSRV 852
            |:    |.|.........|...||.|.|            .:||......:....||
 Worm  2587 IEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEEERLRKEAEE-------- 2643

  Fly   853 TRIRVQSPQIGNSRESLMAQEEEDKEAERDSEEE--------------------EEERDPSERPP 897
             |:|:|.......|:..|..|.|::|..|.:|||                    |:||...|...
 Worm  2644 -RMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKERQEQEARM 2707

  Fly   898 SESPPPPPLPQRRPPTKRPATPPI------YDAVPPP-----------LPVSKPPPPPSVETIPS 945
            .|:.......||....:|....|.      |...|||           .|..:...||:.:. ||
 Worm  2708 REAREAELSRQRMEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQPPNYQQ-PS 2771

  Fly   946 VASL---------PSPAPVTRSMAQRS--------------ASMSRPAKPLVKTSSLRLTYNEQV 987
            ..|:         .:...:..:|.|:.              ..:::|::|...      .||:|.
 Worm  2772 HQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQSFSGPGGINQPSQPGYS------GYNQQG 2830

  Fly   988 RPGDVGKVNKLISRF-------EGGRPRLC---PRRMHSEEYER------CAQPEDEEPEMEQIL 1036
            ..|..|::.:..:.|       :.|..:|.   |...|:::|:.      .||.|.|    :|..
 Worm  2831 GQGQQGQMQQQRNPFGNQQDMQQPGAAKLMHAKPNEAHAQQYQHTQNQLSLAQKEKE----KQYF 2891

  Fly  1037 ELQIIERRAVDSVTPTNR--AVVIPQITVNNNNNNERQLEQSDQSDQSAHQEITDTRKTKSMELA 1099
            :.:.::....::.....|  .||...:........::||..|||...|           :....:
 Worm  2892 QAKNLQASQANAQQQQQRFGDVVAGNVAGYGRPYGQQQLGASDQMGTS-----------QLPGAS 2945

  Fly  1100 LDRQNSNCSRSEYG--------------SPLSFPSSRRSSTPTNLNANSNS-NPNPSTNPNQN 1147
            ..|.|...|..:.|              .|:....|.:...|.......|| .|...|.|.:|
 Worm  2946 TSRMNQGSSNPQGGMQSYQQQQPVLGQPGPIQTGQSTQQQIPAQSQQQYNSGRPQMHTTPTKN 3008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP82	NP_572487.3	None
dpy-22	NP_509645.1	Med12	99..158	CDD:286572
		Med12-LCEWAV	815..>990	CDD:288959
		ARGLU	<2523..2662	CDD:291991	22/147 (15%)
		MAP7	<2623..2729	CDD:283355	24/114 (21%)
		GBP_C	<2630..2728	CDD:303769	23/106 (22%)
		PHA00671	2690..>2760	CDD:106979	14/69 (20%)
		coiled coil	2710..2721	CDD:293879	2/10 (20%)
		RCR	<2728..2784	CDD:304939	11/56 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960