Protein Alignment CG32191 and SULF2

DIOPT Version :10

• Sequence 1: NP_730304.2
• Gene: CG32191 / 317903
• FlyBaseID: FBgn0052191
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001373981.1
• Gene: SULF2 / 55959
• HGNCID: 20392
• Length: 871
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 121/576 - (21%)
• Similarity: 205/576 - (35%)
• Gaps: 221/576 - (38%)

  Fly     3 GLSAFLLLLCLQRVKSDESAAAR--RPNIIIIMADDMGFDDVSF--------------RGGREFL 51
            |.|||   |...|:|.......|  |||||:::.||   .||..              :||..|:
Human    21 GSSAF---LSHHRLKGRFQRDRRNIRPNIILVLTDD---QDVELGSMQVMNKTRRIMEQGGAHFI 79

  Fly    52 -----TPNIDALAYHGRLLDRLYAPAMCTPSRGALLSGRYPIHTGTQHFVISNEE-----PW--- 103
                 ||                   ||.|||.::|:|:| :|   .|...:|.|     .|
Human    80 NAFVTTP-------------------MCCPSRSSILTGKY-VH---NHNTYTNNENCSSPSWQAQ 121

  Fly   104 ------ALTLNATLMPEIFKEAGYSTNLVGKWHLGFSRPEYTPTRRGFDYHFGYWGAYIDYFQRR 162
                  |:.||:|         ||.|...|| :|......|.|..         |..::... :.
Human   122 HESRTFAVYLNST---------GYRTAFFGK-YLNEYNGSYVPPG---------WKEWVGLL-KN 166

  Fly   163 SKMPVANYSL---------GYDFRRNMELECRDRGVYVTDLLTAEAERLIKDHAD--KEQPLFLM 216
            |:.  .||:|         |.|:.::          |:|||:|.::....:....  ..:|:.::
Human   167 SRF--YNYTLCRNGVKEKHGSDYSKD----------YLTDLITNDSVSFFRTSKKMYPHRPVLMV 219

  Fly   217 LSHLAAHTANEDDPL------QAPEEEIQKFSYIKDPNR----------------------RKYA 253
            :||.|.|...:..|.      .|.:.....::|..:|::                      ||..
Human   220 ISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQRKRL 284

  Fly   254 AMISKLDQSVGRIITALSSTDQLENSIVIFYSDNGAPSVGMFSNTGSNFPLRGQKNTPWEGGVRV 318
            ..:..:|.|:..|...|..|.:|:|:.:::.:|:|. .:|.|.       |...|:.|:|..:||
Human   285 QTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGY-HIGQFG-------LVKGKSMPYEFDIRV 341

  Fly   319 AGAIWSSGLQARGSIFRQPLYVADWLPTLSRAADIELDSSLKLDGIDLWPELSGSADAPHVPREI 383
            ...:....::| |.:....:...|..||:           |.:.|:|:..::.|        :.|
Human   342 PFYVRGPNVEA-GCLNPHIVLNIDLAPTI-----------LDIAGLDIPADMDG--------KSI 386

  Fly   384 LHILDD--------------VWRLSAL-QMGQWKYVNGTTASGRYDSVLTYRELDDLDPRDSRYA 433
            |.:||.              |||.|.| :.|:               :|..|:.|.:|.::..:
Human   387 LKLLDTERPVNRFHLKKKMRVWRDSFLVERGK---------------LLHKRDNDKVDAQEENF- 435

  Fly   434 VTVRNSATSRALSRYDLRRLTQQRI-SLTRRLAAVRCGDLQRSCNPLLE--ECLYD 486
                       |.:|       ||: .|.:|      .:.|.:|..|.:  :|:.|
Human   436 -----------LPKY-------QRVKDLCQR------AEYQTACEQLGQKWQCVED 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_730304.2	4-S	27..408	CDD:293753	97/467 (21%)
SULF2	NP_001373981.1	Catalytic domain, necessary for arylsulfatase activity. /evidence=ECO:0000269|PubMed:30788513	1..415		105/482 (22%)
		G6S	43..385	CDD:293766	88/427 (21%)
		DUF3740	529..665	CDD:463628
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..588
		ALP_like	<750..799	CDD:474031