DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32191 and ARSB

DIOPT Version :9

Sequence 1:	NP_001287102.1	Gene:	CG32191 / 317903	FlyBaseID:	FBgn0052191	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_000037.2	Gene:	ARSB / 411	HGNCID:	714	Length:	533	Species:	Homo sapiens

Alignment Length:	567	Identity:	189/567 - (33%)
Similarity:	285/567 - (50%)	Gaps:	95/567 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLCLQRVKSDESAAARRPNIIIIMADDMGFDDVSFRGGREFLTPNIDALAYHGRLLDRLYAPA 72
            ||||.|.......:.|:|.|:::.::|||:|::||.|.|.| ..||::||||..|.|||..|...
Human    26 LLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP 89

  Fly    73 MCTPSRGALLSGRYPIHTGTQHFVISNEEPWALTLNATLMPEIFKEAGYSTNLVGKWHLGFSRPE 137
            :|||||..||:|||.|.||.||.:|...:|..:.|:..|:|::.|||||:|::|||||||..|.|
Human    90 LCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKE 154

  Fly   138 YTPTRRGFDYHFGYWGAYIDYF--QRRSKMPVANYS-LGYDFRRNMELECRDRGVYVTDLLTAEA 199
            ..|||||||.:|||.....||:  :|.:.:...|.: ...|||...|:....:.:|.|::.|..|
Human   155 CLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRA 219

  Fly   200 ERLIKDHADKEQPLFLMLSHLAAHTANEDDPLQAPEEEIQKFSYIKDPNRRKYAAMISKLDQSVG 264
            ..||.:| ..|:||||.|:..:.|     :|||.|||.::.:.:|:|.||..||.|:|.:|::||
Human   220 IALITNH-PPEKPLFLYLALQSVH-----EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVG 278

  Fly   265 RIITALSSTDQLENSIVIFYSDNGAPSVGMFSNTGSNFPLRGQKNTPWEGGVRVAGAIWSSGLQA 329
            .:..||.|:....|::.||.:|||..::.    .|:|:||||:|.:.||||||..|.:.|..|:.
Human   279 NVTAALKSSGLWNNTVFIFSTDNGGQTLA----GGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQ 339

  Fly   330 RGSIFRQPLYVADWLPTLSRAADIELDSSLKLDGIDLWPELSGSADAPHVPREILHILD------ 388
            :|...|:.::::||||||.:.|....:.:..|||.|:|..:|..:.:|.:  |:||.:|
Human   340 KGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRI--ELLHNIDPNFVDS 402

  Fly   389 ------------DVWRL-----------SALQMGQWKYVNGTTASGRYDSVLTYRELDDLDPRDS 430
                        |...|           :|::.|.||.:.|....|.:            .|..|
Human   403 SPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYW------------FPPPS 455

  Fly   431 RYAVTVRNSATSRALSRYDLRRLTQQRISLTRRLAAVRCGDLQRSCNPLLEECLYDILSDPCEQN 495
            :|.|:                                   ::..|..|.....|:||..||.|::
Human   456 QYNVS-----------------------------------EIPSSDPPTKTLWLFDIDRDPEERH 485

  Fly   496 NLVYSERHSDVLTALRRRVQELRASASRPGNRASMPEADPTLHTCAW 542
            :|  |..:..::|.|..|:|.....:......|..|..||.. |..|
Human   486 DL--SREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKA-TGVW 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_001287102.1	AslA	23..458	CDD:225661	164/466 (35%)
		4-S	27..408	CDD:293753	157/412 (38%)
		DUF4976	<478..540	CDD:303608	17/61 (28%)
ARSB	NP_000037.2	AslA	41..489	CDD:225661	173/509 (34%)
ARSB	NP_000037.2	4-S	45..488	CDD:293753	171/504 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157199
Domainoid	1	1.000	290	1.000	Domainoid score	I1555
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2283
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8485
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.660