DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32191 and Arsi

DIOPT Version :9

Sequence 1:	NP_001287102.1	Gene:	CG32191 / 317903	FlyBaseID:	FBgn0052191	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001041346.1	Gene:	Arsi / 307404	RGDID:	1310242	Length:	573	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	187/587 - (31%)
Similarity:	276/587 - (47%)	Gaps:	112/587 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGLSAFLL--LLCLQRVK----------------SDESAAA--RRPNIIIIMADDMGFDDVSFR 45
            |..||.|.|  ||.|..:.                .|:.:||  :.|:||.|:.||.|:.||.:.
  Rat     1 MHALSGFSLVSLLSLGYLSWDWAKPGLVADGPAEAEDQPSAAPPQPPHIIFILTDDQGYHDVGYH 65

  Fly    46 GGREFLTPNIDALAYHGRLLDRLYAPAMCTPSRGALLSGRYPIHTGTQHFVISNEEPWALTLNAT 110
            |. :..||.:|.||..|..|:..|...:|||||..||:|||.||||.||.:|...:|..|.|:..
  Rat    66 GS-DIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQV 129

  Fly   111 LMPEIFKEAGYSTNLVGKWHLGFSRPEYTPTRRGFDYHFGYWGAYIDYFQRRSKMPVANYS---- 171
            .:|:..:||||||::||||||||.|.|..|||||||...|.....:||:         .|.
  Rat   130 TLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYY---------TYDNCDG 185

  Fly   172 ---LGYDFRRNMELECRDRGVYVTDLLTAEAERLIKDHADKEQPLFLMLSHLAAHTANEDDPLQA 233
               .|:|......:.....|.|.|.|....|..::..|: .::||||.::..|.||     |||:
  Rat   186 PGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHS-PQKPLFLYVAFQAVHT-----PLQS 244

  Fly   234 PEEEIQKFSYIKDPNRRKYAAMISKLDQSVGRIITALSSTDQLENSIVIFYSDNGAPSVGMFSNT 298
            |.|.:.::..:.:..|||||||::.:|::|..|..||.......||::||.||||    |...:.
  Rat   245 PREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNG----GQTFSG 305

  Fly   299 GSNFPLRGQKNTPWEGGVRVAGAIWSSGLQARGSIFRQPLYVADWLPTLSRAADIELDSSLKLDG 363
            |||:||||:|.|.||||||..|.:.|..|:.:....|..:::.||.|||...|.....::..|||
  Rat   306 GSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGLAGGTTSAADGLDG 370

  Fly   364 IDLWPELSGSADAPHVPREILHILD---------------DVWRL---SALQMGQWKYVNGTTAS 410
            .|:||.:|....:|..  ||||.:|               .:|..   :|:::|:||.:.|....
  Rat   371 YDVWPAISEGRASPRT--EILHNIDPLYNHARHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGY 433

  Fly   411 GRYDSVLTYRELDDLDPRDSRYAVTVRNSATSRALSRYDLRRLTQQRISLTRRLAAVRCGDLQRS 475
            |           |.:.|:          :..|...|.::|.|:...|.::
  Rat   434 G-----------DWIPPQ----------TLASFPGSWWNLERMASIRQAV--------------- 462

  Fly   476 CNPLLEECLYDILSDPCEQNNLVYSERHSDVLTALRRRVQELRASASRPGNRASMPEADPTLHTC 540
                   .|::|.:||.|:.:|  :::..||:..|..|:.:...:|......|:.|.|.|..:..
  Rat   463 -------WLFNISADPYEREDL--ADQRPDVVRTLLARLADYNRTAIPVRYPAANPRAHPDFNGG 518

  Fly   541 AW 542
            ||
  Rat   519 AW 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_001287102.1	AslA	23..458	CDD:225661	160/461 (35%)
		4-S	27..408	CDD:293753	151/405 (37%)
		DUF4976	<478..540	CDD:303608	15/61 (25%)
Arsi	NP_001041346.1	4-S	48..478	CDD:293753	164/496 (33%)
		AslA	49..485	CDD:225661	165/502 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..550		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351112
Domainoid	1	1.000	308	1.000	Domainoid score	I1294
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H44428
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8957
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.660