DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32191 and SULF1

DIOPT Version :9

Sequence 1:	NP_001287102.1	Gene:	CG32191 / 317903	FlyBaseID:	FBgn0052191	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006716501.1	Gene:	SULF1 / 23213	HGNCID:	20391	Length:	1122	Species:	Homo sapiens

Alignment Length:	684	Identity:	141/684 - (20%)
Similarity:	227/684 - (33%)	Gaps:	276/684 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RPNIIIIMADDMGFDDVSFRGGREFLTPNIDALAYHG-RLLDRLYAPAMCTPSRGALLSGRYPIH 89
            |||||:::.||   .||.. |..:.:......:.:.| ..::......||.|||.::|:|:| :|
Human    42 RPNIILVLTDD---QDVEL-GSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY-VH 101

  Fly    90 TGTQHFVISNEE-----PW---------ALTLNATLMPEIFKEAGYSTNLVGKWHLGFSRPEYTP 140
               .|.|.:|.|     .|         |:.||.|         ||.|...||
Human   102 ---NHNVYTNNENCSSPSWQAMHEPRTFAVYLNNT---------GYRTAFFGK------------ 142

  Fly   141 TRRGFDYHFGYWGAYI-----DYFQRRSKMPVANYSL---------GYDFRRNMELECRDRGVYV 191
                  |...|.|:||     ::..........||::         |:|:.::          |.
Human   143 ------YLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKD----------YF 191

  Fly   192 TDLLTAEAERLIK--DHADKEQPLFLMLSHLAAHTANEDDPLQAPEEEIQKF------------- 241
            |||:|.|:....|  ......:|:.:::||.|.|         .||:...:|
Human   192 TDLITNESINYFKMSKRMYPHRPVMMVISHAAPH---------GPEDSAPQFSKLYPNASQHITP 247

  Fly   242 SYIKDPN------------------------RRKYAAMISKLDQSVGRIITALSSTDQLENSIVI 282
            ||...||                        :||....:..:|.||.|:...|..|.:|||:.:|
Human   248 SYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYII 312

  Fly   283 FYSDNGAPSVGMFSNTGSNFPLRGQKNTPWEGGVRVAGAIWSSGLQARGSIFRQPLYVADWLPTL 347
            :.:|:|. .:|.|.       |...|:.|::..:||...|....::. |||..|.:...|..||:
Human   313 YTADHGY-HIGQFG-------LVKGKSMPYDFDIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTI 368

  Fly   348 SRAADIELDSSLKLDGIDLWPELSGSADAPHVPREILHILD--------------DVWRLSAL-- 396
                       |.:.|:|..|::.|        :.:|.:||              .:||.:.|
Human   369 -----------LDIAGLDTPPDVDG--------KSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVE 414

  Fly   397 -----------------------------------------QMGQ-WKYVNGTTASGRY------ 413
                                                     |.|| |:.:..|:...|.
Human   415 RGKFLRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGP 479

  Fly   414 DSVLTYRE---------LDDLDP----RDSRYAVT----------VRNSATSRALSRYDLRRLTQ 455
            ..:||.|:         ..|.|.    |:|.|..:          :||..|.:...|:...|.|
Human   480 SDLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHTRQT- 543

  Fly   456 QRISLTRRLAAVRCGDLQRSCNPLLEECLYDILSDPCEQNNLV----YSERHSDVLTALRRRVQE 516
                              ||.:...|..:|||..:..|:..::    .::||.:.    .:..::
Human   544 ------------------RSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEG----HKGPRD 586

  Fly   517 LRASASRPGNRASM----------PEADPTLHTC 540
            |:||:.  |||..|          |......|.|
Human   587 LQASSG--GNRGRMLADSSNAVGPPTTVRVTHKC 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_001287102.1	AslA	23..458	CDD:225661	122/586 (21%)
		4-S	27..408	CDD:293753	105/506 (21%)
		DUF4976	<478..540	CDD:303608	16/75 (21%)
SULF1	XP_006716501.1	AslA	42..>386	CDD:225661	96/425 (23%)
		G6S	42..384	CDD:293766	96/423 (23%)
		DUF3740	541..676	CDD:289325	21/103 (20%)
		ALP_like	<768..817	CDD:304875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740