DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32191 and ARSK

DIOPT Version :9

Sequence 1:	NP_001287102.1	Gene:	CG32191 / 317903	FlyBaseID:	FBgn0052191	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_937793.1	Gene:	ARSK / 153642	HGNCID:	25239	Length:	536	Species:	Homo sapiens

Alignment Length:	451	Identity:	99/451 - (21%)
Similarity:	155/451 - (34%)	Gaps:	120/451 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AARRPNIIIIMADDMGFDD-VSFRGGREFL-TPNIDALAYHGRLLDRLYAPA-MCTPSRGALLSG 84
            ||:.||::::::|  .||. ::|..|.:.: .|.|:.:...|......|..: :|.|||.|:.||
Human    28 AAKAPNVVLVVSD--SFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSG 90

  Fly    85 RYPIHTGTQHFVISNEEPW----ALTLNATLMPEIFKEAGYSTNLVGKWHLGFSRPEYTPTRRGF 145
            .:...|          |.|    .|..|.|...::.:..||.|...||.       :||......
Human    91 LFTHLT----------ESWNNFKGLDPNYTTWMDVMERHGYRTQKFGKL-------DYTSGHHSI 138

  Fly   146 DYHFGYWGAYIDYFQRRSKMPVANYSLGYDFRRNMELECRDRGVYVTDLLTAEAERLIKDHADKE 210
            ......|...:.:..|:...|:.|.     .|...::...:|....||   .....|.|:..:..
Human   139 SNRVEAWTRDVAFLLRQEGRPMVNL-----IRNRTKVRVMERDWQNTD---KAVNWLRKEAINYT 195

  Fly   211 QPLFLMLSHLAAHTANEDDPLQAPEEE--------------IQKFSY--IKDPN----------- 248
            :|..:.|.      .|...|..:|...              ::|.|:  ||.|.
Human   196 EPFVIYLG------LNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPLSEMHPVD 254

  Fly   249 ---------------------RRKYAAMISKLDQSVGRIITALSSTDQLENSIVIFYSDNG--AP 290
                                 |..|.||.::.|..:|.||.||...|.|:.:|||:.||:|  |.
Human   255 YYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAM 319

  Fly   291 SVGMFSNTGSNFPLRGQKNTPWEGGVRVAGAIWSSGLQARGSIFRQPLYVADWLPTLSRAADIEL 355
            ....|           .|.:.:|....|...:...|::| |......:.:.|..||:...|.|.|
Human   320 EHRQF-----------YKMSMYEASAHVPLLMMGPGIKA-GLQVSNVVSLVDIYPTMLDIAGIPL 372

  Fly   356 DSSLKLDGIDLWPELSGSADAPHVPREILHILDDVWRLS------------ALQMGQWKYV 404
            ..:  |.|..|.|..|.:....|..:.    |...|.||            .|:...|||:
Human   373 PQN--LSGYSLLPLSSETFKNEHKVKN----LHPPWILSEFHGCNVNASTYMLRTNHWKYI 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_001287102.1	AslA	23..458	CDD:225661	99/451 (22%)
		4-S	27..408	CDD:293753	97/447 (22%)
		DUF4976	<478..540	CDD:303608
ARSK	NP_937793.1	ARSK	32..447	CDD:293781	97/447 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740