DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32191 and Arsb

DIOPT Version :9

Sequence 1:	NP_001287102.1	Gene:	CG32191 / 317903	FlyBaseID:	FBgn0052191	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_033842.3	Gene:	Arsb / 11881	MGIID:	88075	Length:	534	Species:	Mus musculus

Alignment Length:	571	Identity:	182/571 - (31%)
Similarity:	276/571 - (48%)	Gaps:	105/571 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLCLQRVKSDESAAARRPNIIIIMADDMGFDDVSFRGGREFLTPNIDALAYHGRLLDRLYAPA 72
            ||||.|...::  |.|.:.|:::.::|||:|::|:.|.|. ...||::||||..|.:||..|...
Mouse    29 LLLLLLSPARA--SGATQPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQP 90

  Fly    73 MCTPSRGALLSGRYPIHTGTQHFVISNEEPWALTLNATLMPEIFKEAGYSTNLVGKWHLGFSRPE 137
            :|||||..||:|||.||.|.||::|...:|..:.|:..|:|::.|||||:|::|||||||..|.|
Mouse    91 LCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKE 155

  Fly   138 YTPTRRGFDYHFGYWGAYIDYFQRRSKMPVANYS---LGYDFRRNMELECRDRGVYVTDLLTAEA 199
            ..|||||||.:|||.....||:...:..|:.:.:   ...|.|...|.......:|.|::.|..|
Mouse   156 CLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGTRCALDLRDGEEPAKEYNNIYSTNIFTKRA 220

  Fly   200 ERLIKDHADKEQPLFLMLSHLAAHTANEDDPLQAPEEEIQKFSYIKDPNRRKYAAMISKLDQSVG 264
            ..:|.:| ..|:||||.|:..:.|     ||||.|||.::.:.:|:|.:||.||.|:|.:|::||
Mouse   221 TTVIANH-PPEKPLFLYLAFQSVH-----DPLQVPEEYMEPYGFIQDKHRRIYAGMVSLMDEAVG 279

  Fly   265 RIITALSSTDQLENSIVIFYSDNGAPSVGMFSNTGSNFPLRGQKNTPWEGGVRVAGAIWSSGLQA 329
            .:..||.|.....|::.||.:|||    |...:.|:|:||||:|.|.||||:|..|.:.|..|:.
Mouse   280 NVTKALKSHGLWNNTVFIFSTDNG----GQTRSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQ 340

  Fly   330 RGSIFRQPLYVADWLPTLSRAADIELDSSLKLDGIDLWPELSGSADAPHVPREILHIL------- 387
            :|...|:.:::.||||||...|....:.:..|||.::|..:|....:|.|  |:||.:
Mouse   341 KGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRV--ELLHNIDQDFFDG 403

  Fly   388 ------------DDVWRL----------SALQMGQWKYVNGTTASGRY---DSVLTYRELDDLDP 427
                        ||.:.|          :.::...||.:.|....|.:   .|.....|:..:||
Mouse   404 LPCPGKNMTPAKDDSFPLEHSAFNTSIHAGIRYKNWKLLTGHPGCGYWFPPPSQSNVSEIPPVDP 468

  Fly   428 RDSRYAVTVRNSATSRALSRYDLRRLTQQRISLTRRLAAVRCGDLQRSCNPLLEECLYDILSDPC 492
                                                              |.....|:||..||.
Mouse   469 --------------------------------------------------PTKTLWLFDINQDPE 483

  Fly   493 EQNNLVYSERHSDVLTALRRRVQELRASASRPGNRASM-PEADPTLHTCAW 542
            |::::  |..|..::..|..|:|... ..|.|.:...: |..||. .|..|
Mouse   484 ERHDV--SREHPHIVQNLLSRLQYYH-EHSVPSHFPPLDPRCDPK-STGVW 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32191	NP_001287102.1	AslA	23..458	CDD:225661	157/469 (33%)
		4-S	27..408	CDD:293753	151/412 (37%)
		DUF4976	<478..540	CDD:303608	17/62 (27%)
Arsb	NP_033842.3	AslA	42..490	CDD:225661	164/512 (32%)
Arsb	NP_033842.3	4-S	46..489	CDD:293753	163/507 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847586
Domainoid	1	1.000	307	1.000	Domainoid score	I1340
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8720
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.660