DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otu and ALG13

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_011529330.1	Gene:	ALG13 / 79868	HGNCID:	30881	Length:	1161	Species:	Homo sapiens

Alignment Length:	1054	Identity:	226/1054 - (21%)
Similarity:	355/1054 - (33%)	Gaps:	384/1054 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEKEIPGDFDSY 85
            |:||.|.||:||.||:|||.|||.|:||::.:|:.|.|||..||.:|...::.||..:.|.|:.|
Human   223 DEYLGSLGLFRKLTAKDASCLFRAISEQLFCSQVHHLEIRKACVSYMRENQQTFESYVEGSFEKY 287

  Fly    86 MQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNENHFDSVYDV 150
            ::.:..||......|:||:|.:|.|:.|||.......:.|.:..|.:...:.:::..|:||||..
Human   288 LERLGDPKESAGQLEIRALSLIYNRDFILYRFPGKPPTYVTDNGYEDKILLCYSSSGHYDSVYSK 352

  Fly   151 EYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFNWDRFNVEFDDKGYMVRIHCTDGRV 215
            ::...||:||::.:::||:.:|.:.:......|.|.......:|.|.            .|....
Human   353 QFQSSAAVCQAVLYEILYKDVFVVDEEELKTAIKLFRSGSKKNRNNA------------VTGSED 405

  Fly   216 FKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGSSGHEPNDLLPMCPN 280
            ...|........:|.:..| :::.|..:..|         |..||.|:            |..|:
Human   406 AHTDYKSSNQNRMEEWGAC-YNAENIPEGYN---------KGTEETKS------------PENPS 448

  Fly   281 RLESCVRQLLDDGISPFPYKVAKSMDPYMYRNIEFDCWNDMRKEAKLYNVYINDY------NFKV 339
            ::             ||||||.|::||.:|||:|||.|.|.|||.:.     :||      .:.:
Human   449 KM-------------PFPYKVLKALDPEIYRNVEFDVWLDSRKELQK-----SDYMEYAGRQYYL 495

  Fly   340 GAKCKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLHPLP-------------- 390
            |.||:|.|.:|...|..|:|.:..:.|...||:|.:.::.|||..:|.|:.
Human   496 GDKCQVCLESEGRYYNAHIQEVGNENNSVTVFIEELAEKHVVPLANLKPVTQVMSVPAWNAMPSR 560

  Fly   391 --------PDEYRPW----------------------------------SLPFR----------- 402
                    |..|.|.                                  .||.|
Human   561 KGRGYQKMPGGYVPEIVISEMDIKQQKKMFKKIRGKEVYMTMAYGKGDPLLPPRLQHSMHYGHDP 625

  Fly   403 ----------------YHRQ-----------MPR----------LPLPK---YAGK--------- 418
                            :|.|           |||          :|.||   |.|.
Human   626 PMHYSQTAGNVMSNEHFHPQHPSPRQGRGYGMPRNSSRFINRHNMPGPKVDFYPGPGKRCCQSYD 690

  Fly   419 ------------------ANKSSKW--------KKNKLFEMDQYFEHSKCDLMPY---------- 447
                              .||.|::        ....|.|...::|..:.|...|
Human   691 NFSYRSRSFRRSHRQMSCVNKESQYGFTPGNGQMPRGLEETITFYEVEEGDETAYPTLPNHGGPS 755

  Fly   448 --MPVDNCY-----------QGVHIQDDEQRDHN-------------DPEQNDQNPTTEQRDR-- 484
              :|..:.|           |.:::::...:..|             |.|.:....||.....
Human   756 TMVPATSGYCVGRRGHSSGKQTLNLEEGNGQSENGRYHEEYLYRAEPDYETSGVYSTTASTANLG 820

  Fly   485 ----------------EEPQAQKQHQRTKASRVQPQNSSSSQN--QEVSGSAAPPPTQYMNYVP- 530
                            ..|...|..|..|:..:.||::.:|.|  |::.|:.|.......|.||
Human   821 LWLYLNTDFGIVHVKWGSPFHSKSLQDRKSCSMSPQDTVTSYNYPQKMMGNIAAVAASCANNVPA 885

  Fly   531 ----------------MIPS----RPGHLPPPWPASPMAIAEEFP----FPISGTPHPPPTEGCV 571
                            .:.|    :|..:.||....|:..:..:|    .|.:|...|||
Human   886 PVLSNGAAANQAISTTSVSSQNAIQPLFVSPPTHGRPVIASPSYPCHSAIPHAGASLPPP----- 945

  Fly   572 YMPFGGYGPPPPGAVALSGPHPFMPLPSPPLNVTGIGE------------PRRSLHPNGEDLPVD 624
                    ||||.......|.|..|.|.||.....:||            |..|..|:|.|||.|
Human   946 --------PPPPPPPPPPPPPPPPPPPPPPPPALDVGETSNLQPPPPLPPPPYSCDPSGSDLPQD 1002

  Fly   625 MVTLRYFYNMGVDLHWRMSHHTPPDELGMFGYHQQNNTDQQAGRTVVIGATEDNLTAVESTPPPS 689
            ...|:|::|:|:..::....|:                      .|.:...:..| .||:.|
Human  1003 TKVLQYYFNLGLQCYYHSYWHS----------------------MVYVPQMQQQL-HVENYP--- 1041

  Fly   690 PEVANATEQSPLEKSAYAKRNLNSVKVRGKRPEQLQDIKDSLGPAAFLPTPTPSPSSNGSQFSFY 754
                           .|.:..|....|    |:...:::...|..|........|:::.|..
Human  1042 ---------------VYTEPPLVDQTV----PQCYSEVRREDGIQAEASANDTFPNADSSSV--- 1084

  Fly   755 TTPSPH---HHLITPPRLLQPPPP---------------PPIFYHKAGPPQLGGAAQ-----GQT 796
                ||   ::.:......|||.|               ||  :|..| ...||::|     ...
Human  1085 ----PHGAVYYPVMSDPYGQPPLPGFDSCLPVVPDYSCVPP--WHPVG-TAYGGSSQIHGAINPG 1142

  Fly   797 PYAWGMPAPVVSPY 810
            |.....|:|..|.|
Human  1143 PIGCIAPSPPASHY 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	31/77 (40%)
		TUDOR	335..392	CDD:197660	19/84 (23%)
		TAF12	<446..>564	CDD:304643	31/198 (16%)
ALG13	XP_011529330.1	Glycosyltransferase_GTB_type	4..>120	CDD:299143
		OTU	239..345	CDD:303090	35/105 (33%)
		TUDOR	496..544	CDD:119391	17/47 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I4407
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3394
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8659
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.890