DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and itprid2

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001072601.3	Gene:	itprid2 / 780056	XenbaseID:	XB-GENE-981013	Length:	1225	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	134/757 - (17%)
Similarity:	228/757 - (30%)	Gaps:	256/757 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGS---SGHEPNDLLPMCPNRL 282
            ||.|:..||:..|............:..:..|.|..|.:..:.:.|   ..||.          |
Frog   543 PGSTDFDLEDQFLTPSFMVESKAFFSDHQESRAESLNMDSEQINPSEECKSHED----------L 597

  Fly   283 ESCVRQLLDDGISPFPYKVAKSMD--------PYMYRNIEFDCWNDMRKEAKLYNVYINDYNFKV 339
            .|.:..:.::...|..|.....:|        ||...:|           ::|.:.| :||.:.:
Frog   598 HSAMECIAEESDLPQDYIAESEIDTGSEYETVPYTTHHI-----------SELVDSY-SDYEYNL 650

  Fly   340 GAKCKVELPNETEMYTCHVQNISKDKNYCHVFVER---------------------IGKEIVVPY 383
               |:.|            :|.|...:..||.::|                     ..|:::...
Frog   651 ---CRSE------------KNSSCSLDRVHVALQRAQMKVLSSSGEASSRTGRSMITSKDLIKKR 700

  Fly   384 ESL----HPLPPDEYRPWSL--PFRYHRQMPRLPLPKYAGKANKSSKWKKNKLFEMDQYFEHSKC 442
            |:.    :||...:..|.:|  |.|.   :.::.:...:|||...|          ...|.:.
Frog   701 ENFSNSGYPLRRTQSLPSALLNPVRV---VSKVNIVLTSGKATVCS----------PPTFSYK-- 750

  Fly   443 DLMPYMPVDNCYQGVHIQDDEQRDHNDPEQNDQ----NPTTEQRDR---------EEPQAQKQHQ 494
                |.|.:        :|..::...||..|.:    :|.:|.::.         |:|..:.|..
Frog   751 ----YTPEE--------EDCLEQIEEDPNTNSKPDYISPKSELKEMHKSGPHKIPEDPHPRPQSC 803

  Fly   495 RTKASRVQPQNSSSSQNQEVSGSAAPPPTQY-----MNYVPMIPSRP-GHLPPPWPASPMAIAEE 553
            .|.||  ....||.|.:..:|.....|...:     .:.||.....| |:...|:..   .:|..
Frog   804 TTHAS--HRSQSSCSLHSLLSDWHEKPLCDHGRAWSTHSVPNFSGAPCGNFISPFTC---PVASR 863

  Fly   554 FPFPISGTPHPPPTEGCVYMPFGGYGPPPPGAVALSGPHPFMPLPSPPLNV-------------T 605
            ||:   |:.| ....||. :|...    ||....:........:.|...|:             :
Frog   864 FPY---GSLH-RSCSGCT-LPVNS----PPSTTEMQLRRVLHDIRSSLQNLSQHSVMRGSDGSAS 919

  Fly   606 GIGEPRRSLHP----NGEDLPVDMVTLRYFYNMGVDLHWRM--------SHHTPPD--------- 649
            |....|.|:.|    ..::|.:...:|..|....:||...|        .|.|..:
Frog   920 GFSMQRSSVLPLYENTFQELQIMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEDERYEADQLQG 984

  Fly   650 -----------------------ELGMFGYHQQNNTDQQAGRTVVIGATEDNLTAVESTPPPSPE 691
                                   |..:..:|..:...:.:...:..|.:.|||..........|.
Frog   985 LRNSVRMELQELELQLDERLLALEEQLRNFHVSSPFQRHSAMGMYRGRSTDNLAFSSPLNVIEPV 1049

  Fly   692 VANATEQSPLEKSAYAKRNLNSVKVRG------------------KRPEQLQDIKDSLGPAAFLP 738
            .....||:.| ||.....:|:....|.                  |..:.|....||:..:
Frog  1050 TELIREQTHL-KSELGLEDLSIGHGRDRCDSMASDNSSLYSSPLHKHKKGLTSSCDSIDKS---- 1109

  Fly   739 TPTPSPSSNGSQFSFYTTPSPHHHLITPPRL--LQPPPPPPIFYHKAGPPQLGGAAQGQTPYAWG 801
            .|..|||.|..:.|...||||      |.|.  :|.|                  ...::|..:|
Frog  1110 KPHASPSKNVFRASVALTPSP------PAREGDIQKP------------------VNDESPENYG 1150

  Fly   802 MPAPVVSPYEVINNYNMDPSAQPQQQQPATLQPAPLSVQSQP 843
                         ...::|:.:|:|...|:  ||..|.:..|
Frog  1151 -------------KLKVEPTEKPEQVSFAS--PANESTRWSP 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090
		TUDOR	335..392	CDD:197660	12/81 (15%)
		TAF12	<446..>564	CDD:304643	28/136 (21%)
itprid2	NP_001072601.3	KRAP_IP3R_bind	136..282	CDD:405421
itprid2	NP_001072601.3	SSFA2_C	835..1011	CDD:405422	30/187 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165164697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930