DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and otud4

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001072598.1	Gene:	otud4 / 780053	XenbaseID:	XB-GENE-5900161	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	905	Identity:	195/905 - (21%)
Similarity:	330/905 - (36%)	Gaps:	252/905 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEKEIPGDFDSY 85
            |.||.|.|||||..|:|.|.|||.:|||:..:|..|.:||..|:.::...|..:|..|.|.|:.|
Frog    20 DSYLRSEGLYRKKIAKDGSCLFRAVAEQVMHSQSEHLKIRKSCINYLRKNRGQYEALIEGSFEDY 84

  Fly    86 MQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNENHFDSVYDV 150
            ::.:..|:.:....|:.|:|.:::::.|:|:..|:..:.|....::|...:.|:|.||:|.:|.:
Frog    85 LKSLENPQEWVGQVEISALSLMFKKDFIIYQEPNVPPACVTENGFSEKIMLCFSNGNHYDIIYPI 149

  Fly   151 EYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFNWDRFNVEFDDKGYMV--RIHCTDG 213
            .:.|.||:||||.::|||:|:..:                |..::.||.|..|...  .::|:||
Frog   150 GFAESAAMCQSIIYELLYEKVMGV----------------NVGKYMVEQDTCGPNATGEVYCSDG 198

  Fly   214 RVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGSSGHEPNDLLPMC 278
            .      ..:...:.:|.| .||...||             .|..::.|.......||. :||
Frog   199 S------GSEGEDVSKNIK-TNFADMNG-------------FKPHKDDKCPQKKKEEPT-MLP-- 240

  Fly   279 PNRLESCVRQLLDDGISPFPYKVAKSMDPYMYRNIEFDCW-NDMRKEAKLYNVYINDYNFKVGAK 342
                                 .|.:|:....|||:|::.| ...|.:.||.........:.||.|
Frog   241 ---------------------SVLRSLHTTQYRNVEYEVWLKTQRDQQKLDFSIAAGMQYSVGDK 284

  Fly   343 CKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLHPLPPD--EYRPW-------- 397
            |:|.:....:.|..|:|.:..:.....||||.:|::..|..:.|.|:|..  ....|
Frog   285 CQVRVEPGGKFYNAHIQEVGTETGPVIVFVEELGEKHAVQLKHLKPIPQTIISTEGWNTVAGKKQ 349

  Fly   398 --SLPFRYHRQMPR---------LPLPKYAGKANKSSKWKKNKLF--------EMDQYFEHSKCD 443
              :||...:.|..:         .|:.:.|.:..:..:...||.:        :..|.....:..
Frog   350 KKALPSGTNAQTEKDYRGQKGFGKPVKQQAAQPLRQQQAAGNKQYGLSSQLSDQAPQSENKGRSK 414

  Fly   444 LMPYMP--------VDNCYQGVHIQDDEQRDHND------------------------------- 469
            ..|.:|        .:|...|:.:::.::::..:
Frog   415 TPPKVPGRKVERERSENVTFGLTVEERKEKEAIEESKSLYEMQSMDKDAFPALSSLPIGERAVQN 479

  Fly   470 ----PEQNDQNPTTEQRDREEPQAQKQHQRTKASRVQPQNSSSSQ------NQEVSGSAAPPPTQ 524
                |.:...|..||...|   :::.:.||.|||..|.......:      .|..|..|...|:.
Frog   480 TEVFPVKRIPNVITENTRR---KSEGEDQRDKASTAQATKGRDQKCCDETVKQLTSSDADDLPSM 541

  Fly   525 YM-------NYVPMIPSRPGHLPPPWPASPMAIAEEFPFPISGTPHPPPTEGCVYMPFGGYGPPP 582
            .:       ...|::||.|. :...||..|..|..     :|.|    .::..|..|.....|.|
Frog   542 PVLRTSAEHQASPIVPSTPS-VVTSWPGIPAQIPS-----MSAT----GSDSSVLQPQVTSSPYP 596

  Fly   583 PGAVALSGPH-PFMPLPSP------------PLNVTG--IGEPRRSLHPNGEDLPVDMVTLRYFY 632
            |..|::...: |.:|||..            |||..|  ...|..|...||.|||.|...||:|:
Frog   597 PLPVSVPAVNQPLLPLPQTLSALQDPLYPGFPLNEKGERATVPSYSFCKNGGDLPDDKSILRFFF 661

  Fly   633 NMGVDLH----WRMSHHTPPDELGMFGYHQ----------------QNNTDQQAGRTVVIGATED 677
            |:|:..:    |       |....::..||                |.:..|:         |.:
Frog   662 NLGLKAYTYPMW-------PPHTHLYPLHQAYLNMCRMYPNIPVYPQGSWVQE---------TSE 710

  Fly   678 NLTAVESTPPPSPEVANATEQSPLEKSAYAKRNLNSVKVR-----GKRPEQLQ------------ 725
            |.:.|:      |.:.:...:..:|........::|..|:     |:.|.|.:
Frog   711 NQSEVD------PSLLSHPSEVRMESQGSQPLTVSSSPVQVPGIVGQIPNQSESGVINQALHTNV 769

  Fly   726 DIKDSLGPAAFLPTPTPSPSSNGSQFSFYTTPSPH-----------------HHLITPPR 768
            |.:|........|.|..:.||........|...||                 |::..||:
Frog   770 DFEDPATSKTIFPQPPFAQSSYMGAVPIATPYFPHFWYGYPYQGYIESPVIRHNVYIPPQ 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	24/77 (31%)
		TUDOR	335..392	CDD:197660	17/56 (30%)
		TAF12	<446..>564	CDD:304643	29/173 (17%)
otud4	NP_001072598.1	OTU	36..>115	CDD:303090	24/78 (31%)
otud4	NP_001072598.1	TUDOR	282..330	CDD:119391	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5243
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3641
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9555
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960