DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and Otud4

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001242962.1	Gene:	Otud4 / 73945	MGIID:	1098801	Length:	1107	Species:	Mus musculus

Alignment Length:	947	Identity:	215/947 - (22%)
Similarity:	348/947 - (36%)	Gaps:	259/947 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEK 76
            |..:...|.|.||...|||||..|:|.|.|||.:|||:..:|..|.|:|:.|:|::...|..||.
Mouse    17 GPLEDETPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIRYLRENREKFEA 81

  Fly    77 EIPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNE 141
            .|.|.|:.|::.:..|:.:....|:.|:|.:||::.::|:..|:..|.|....:.|...:.|:|.
Mouse    82 FIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFVIYQEPNVSPSHVTENNFPEKVLLCFSNG 146

  Fly   142 NHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFN-WDRFNVEFDDKGYM 205
            ||:|.||.:.|.:.:|:|||:.::|||:|:|| .|||   :||:...... .:..|.|..|.
Mouse   147 NHYDIVYPITYKDSSAMCQSLLYELLYEKVFK-TDVS---KIMMGLEASEVAEESNSEISDS--- 204

  Fly   206 VRIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGSSGHE 270
                            .|.:|              .::|..|......:....|..|.:|:|.
Mouse   205 ----------------EDDSC--------------KSKSTAATDVNGFKPSGSENPKNNGNSA-- 237

  Fly   271 PNDLLPMCPNRLESCVRQLLDDGISPFPYKVAKSMDPYMYRNIEFDCW--NDMRKEAKLYNVYIN 333
              ||                     |...||.||::|.:|||:|::.|  :...::.:.|::...
Mouse   238 --DL---------------------PLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAG 279

  Fly   334 DYNFKVGAKC-KVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLHPLPPD----- 392
             ..::||.|| :|.|.:..::....:..:..:...  |..|.:||:...  ::|.|.||:
Mouse   280 -LQYEVGDKCHQVRLDHNGKLSNADIHGVHSENGL--VLSEELGKKHTP--KNLKPPPPESWNTV 339

  Fly   393 ------------------EYR-----------PWSLPFRYHRQMPRLPLP------------KYA 416
                              :||           |.:||       |||..|            ...
Mouse   340 SGKKMKKPNSGQNFHSDTDYRGPKNLNKPIKAPSALP-------PRLQHPSSGVRQHAFSSHSTG 397

  Fly   417 GKANKSSKWKKNKLFEMDQYF----EHSKCDLMPYMPVDNCYQGVHIQDDEQRD----------- 466
            .::.|||...|| |..|....    :..:.:...::..::.|.|  :..:|:|:
Mouse   398 SQSQKSSSEHKN-LSRMPSQITRKPDRERAEDFDHVSRESYYFG--LSPEERREKQAIEESRLLY 459

  Fly   467 ------------------HNDPEQNDQ----NPTTEQRDRE--------EPQAQKQHQR------ 495
                              ...|.||..    ..::..|||:        |.:..|...|
Mouse   460 EIQNRDEQAFPALSSSSVSQSPSQNSNACVPRKSSHARDRKGSMRRADAEERKDKDSLRGHTHVD 524

  Fly   496 ------------TKASRVQPQNSSSSQNQEVSGSAAPPPTQYM---NYVPMIPSRPGHLPPPWPA 545
                        .|.:||   :|.|...:|........|.:::   |..|::.|...||.|..|:
Mouse   525 KKPEPSTLEISDDKCTRV---SSPSKSKKECPSPVEQKPAEHIPLSNPAPLLVSPEVHLTPAVPS 586

  Fly   546 SPMAI----AEEFPFPISGTPHPPP------TEGCVYMPFGGYGPPPPGAVALSGPH-PFMPLPS 599
            .|..:    :|...|..:|.|...|      |.|........:..|.|..|::...: |.||||.
Mouse   587 LPATVPAWPSEPTTFGPTGVPAQIPILSVTQTTGPDAAVSQAHLTPSPVPVSIQAVNQPLMPLPQ 651

  Fly   600 ----------PPLNVTGIGE----PRRSLHPNGEDLPVDMVTLRYFYNMGVDLH----WRMSHHT 646
                      |....:..|:    |..||...|||||.|...||:|:|:||..:    |....:
Mouse   652 TMSLYQDPLYPGFPCSEKGDRAIAPPYSLCQTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSY- 715

  Fly   647 PPDELGMFGYHQQNNTDQQAGRTVVIGATEDNLTAVESTPPPSPEVANATEQSPLEKSAYAKRNL 711
                  ::..||......:....|.:.....| |..:..||     |.:....|...:.|:..
Mouse   716 ------LYPLHQAYMAACRMYPKVPVPVYPQN-TWFQEAPP-----AQSESDCPCTDAHYSLH-- 766

  Fly   712 NSVKVRGKRPEQLQDIKDSLGPAAF---LPTPTPSPSSNGSQFSFYTTPSPHHHLITPPRLLQPP 773
            ....|.|:.|:.      .:||.||   |..|....|....|.|:    .|......|.:||...
Mouse   767 PEASVNGQMPQA------EMGPPAFASPLVIPPSQVSEGHGQLSY----QPELESENPGQLLHAE 821

  Fly   774 PPPPIFYHKAGPPQLGGAAQGQTPYAWGMPAPVVSPY 810
            ....:......|.|    :.|..|:..  |.|:..|:
Mouse   822 YEESLSGKNMYPQQ----SFGPNPFLG--PVPIAPPF 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	27/77 (35%)
		TUDOR	335..392	CDD:197660	13/57 (23%)
		TAF12	<446..>564	CDD:304643	32/183 (17%)
Otud4	NP_001242962.1	Cys-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	39..45		2/5 (40%)
		OTU	42..>121	CDD:303090	27/78 (35%)
		Variable-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	94..104		1/9 (11%)
		His-loop. /evidence=ECO:0000250\|UniProtKB:Q5VVQ6	143..148		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..239		11/80 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..431		20/118 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..568		16/100 (16%)
		T4BSS_DotH_IcmK	558..>644	CDD:289093	19/85 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1107
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835252
Domainoid	1	1.000	139	1.000	Domainoid score	I4810
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3546
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8894
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.920