DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and alg13

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_005161471.1	Gene:	alg13 / 557181	ZFINID:	ZDB-GENE-060307-1	Length:	889	Species:	Danio rerio

Alignment Length:	981	Identity:	222/981 - (22%)
Similarity:	344/981 - (35%)	Gaps:	340/981 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEKEIPGDFDSY 85
            |:||.|.|||||..|||||.|||.::||:|.:|..|..||.|||.|:...|..||..:.|.|:.|
Zfish    13 DEYLASIGLYRKMMARDASCLFRAVSEQLYYSQNYHQRIRKECVNFIRANRCNFEPFVEGSFEKY 77

  Fly    86 MQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNENHFDSVYDV 150
            ::.:..||.......::|:|.||||..::|.......:.:..........:..:|..|:|.||..
Zfish    78 LERLEDPKETVGQVIIKALSLLYRRCFVIYRYPGKPPTEIAEEDNLPKILLCCSNNGHYDIVYPK 142

  Fly   151 EYIERAAICQSIAFKLLYQKLFKLPD--VSFAVEIMLHPHTFNWDRFNVEFDDKGYMVRIHCTDG 213
            .|...||:||::.::|||.::..:.|  :..|:|                 ..||        .|
Zfish   143 SYPVDAAVCQALLYELLYTRVLGVEDNEIQAALE-----------------GFKG--------GG 182

  Fly   214 RVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERKASGSSGHEPNDLLPMC 278
            |.::           .::.:|:..::....            :::.:|:...|.||        |
Zfish   183 RRYR-----------NSHSMCSEDASYDTP------------EDRSQREDWESRGH--------C 216

  Fly   279 PNRLESCVRQLLDD-------GISPFPYKVAKSMDPYMYRNIEFDCWNDMRKEAKL--YNVYIND 334
              |.:...|...:|       |....||||.|:::|.:|||:|||.|.|.|||.:.  |.|:...
Zfish   217 --RFDDRPRVGAEDQKVTEGSGKLALPYKVLKALEPELYRNVEFDVWQDSRKELQKTDYMVFAGR 279

  Fly   335 YNFKVGAKCKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLHPLPPDEYRPWSL 399
            ..| :|.||:|.|..:.:.|...:|.:........||:|.:|::.:|...:|.|:.|  ...|::
Zfish   280 QYF-LGDKCQVRLDPKGKYYNAFIQEVGTHSTAVTVFIEELGEKHLVSLTNLKPVNP--VPAWNI 341

  Fly   400 -PFRYHRQMPRLPLPKYAGKANKSSKWKKNKLFEMDQYFEHSKCDLMPYMPVDNCYQGVHIQDDE 463
             |.|                       |.|.....:||
Zfish   342 TPSR-----------------------KGNSYSHAEQY--------------------------- 356

  Fly   464 QRDHNDPEQNDQNPTTEQRDREEPQAQKQHQRTKASRVQPQNSSSSQNQEVSGSAAPPPTQYMNY 528
                  |.:.|......:|..::|:.::.......||.||              ..||..|
Zfish   357 ------PGELDPELRGRRRFFKKPRGKEMLMAVSFSRPQP--------------GLPPRLQ---- 397

  Fly   529 VPMIPSRPGHLPP--------PWPASPMAIAEEFPFPISGTPHPPPTEGCVYMPFGGYGPPPPGA 585
                |. ||::.|        |.|..|..|.|.:      .|||||.:.      .|||||....
Zfish   398 ----PG-PGNIHPVRSPGVHSPAPPPPGLIYEHY------RPHPPPRQP------RGYGPPSSAR 445

  Fly   586 VA----LSGPH-PFMPLPSPPLNVT------GIGEPRRSLHPNGED----LPVDMVTLRYFYNMG 635
            ..    |.||. .:.|.||.....:      .....||.:|...::    :|
Zfish   446 FLNRHHLIGPDMAYYPSPSKRCYQSFDNYSFRSRRSRRQMHTLNKECLSCVP------------- 497

  Fly   636 VDLHWRMSHHTPPDEL----GMFGYHQQNNTDQQA-----GRTV----VIGATEDNLTAVESTPP 687
                      .|.:|.    |...:::...||:.|     |:.|    |.|||...:..|.|..|
Zfish   498 ----------EPGEETQDMEGSITFYELEETDEGAFSPISGQAVSSPMVPGATAYWVPRVPSPIP 552

  Fly   688 PSPEVA-NATEQSPLEKSA------YAKRNLNSVKVRGKR------------------------- 720
            ||.:.| .::|:.|.|:||      |::..:.|....|.:
Zfish   553 PSGKQAMTSSEEDPDERSAGGDQGEYSEEYIYSAAEAGYQSPSVYAAAAESTTNLTIQEGSSRAG 617

  Fly   721 -PE---------QLQDIKDSL---------GPAAFLPTPTPSPSSNGSQFSFYTTPS--PHHHLI 764
             |:         |...:|.|:         .|||...:.:.|.|:..||    |.|:  ..::::
Zfish   618 SPQEGVATYSYSQQVVVKSSVLSSSQPINSAPAAIFTSNSSSSSTGSSQ----TPPNSLQPNNIL 678

  Fly   765 TPPRLLQPP-------------------PPPPIFYHKAGP------------------------- 785
            ||.:|  ||                   ||||..|...|.
Zfish   679 TPGQL--PPGRPAVPWFVNELGEPVAMAPPPPYSYDPNGSDLPRDCKVLQYYYNLGVQWYQQSYW 741

  Fly   786 ----------PQLGGAAQGQTPYAWGMPAPVVSPYEVINNYNMDPSAQPQQQQPATLQPAPLSVQ 840
                      |.....||.|:..:...||....|....::..|.|  .||...|:  ..|||.::
Zfish   742 HSMVHLQQVYPHQAADAQFQSYQSTAPPADHTVPQAYPDSVRMCP--HPQGDMPS--NGAPLGME 802

  Fly   841 SQPAAV 846
            :.|..|
Zfish   803 NPPTVV 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	31/77 (40%)
		TUDOR	335..392	CDD:197660	15/56 (27%)
		TAF12	<446..>564	CDD:304643	21/125 (17%)
alg13	XP_005161471.1	OTU	29..>108	CDD:303090	31/78 (40%)
alg13	XP_005161471.1	TUDOR	284..332	CDD:119391	13/47 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10322
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007272
OrthoInspector	1	1.000	-	-		mtm6497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.840