DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otu and OTUD5

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_005278096.1	Gene:	OTUD5 / 55593	HGNCID:	25402	Length:	572	Species:	Homo sapiens

Alignment Length:	217	Identity:	52/217 - (23%)
Similarity:	97/217 - (44%)	Gaps:	33/217 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QAPDP---------YDQYL-ESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTL 69
            :|.||         :::.| :.:|...|....|.:.|||.:|:|:|..|.:|..:|..|:.::..
Human   189 EAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMK 253

  Fly    70 KRRIFEKEIPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVV--------F 126
            ....|...:..||.:|:....|...:|...|::||:.:|.|.|.:|: |:.|||.|        .
Human   254 NADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQ-YSTGTSAVEPINTFHGI 317

  Fly   127 NRRYAENFRVFFNNENHFDSVYDVEYIERAAICQSI---AFK------LLYQKLFKLPDVSFAVE 182
            ::...|..||.::...|::||.:.   .:|.|...:   :||      .|.:...|..:.|:..:
Human   318 HQNEDEPIRVSYHRNIHYNSVVNP---NKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQ 379

  Fly   183 IMLH--PHTFNWDRFNVEFDDK 202
            .||.  ....:|:..|...:::
Human   380 QMLEDKKRATDWEATNEAIEEQ 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	23/77 (30%)
		TUDOR	335..392	CDD:197660
		TAF12	<446..>564	CDD:304643
OTUD5	XP_005278096.1	OTU	221..335	CDD:303090	32/114 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860