DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and OTUD4

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_011530342.2	Gene:	OTUD4 / 54726	HGNCID:	24949	Length:	1121	Species:	Homo sapiens

Alignment Length:	977	Identity:	223/977 - (22%)
Similarity:	348/977 - (35%)	Gaps:	331/977 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SGSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFE 75
            :|.|:...|.|.||...|||||..|:|.|.|||.:|||:..:|..|.|:|:.|:.::...|..||
Human    16 AGPREDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFE 80

  Fly    76 KE-------IPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAEN 133
            ..       |.|.|:.|::.:..|:.:....|:.|:|.:||::.|:|...|:..|.|....:.|.
Human    81 AVTCNFKHFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEK 145

  Fly   134 FRVFFNNENHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFN-WDRFNV 197
            ..:.|:|.||:|.||.::|.|.:|:|||:.::|||:|:|| .|||   :|::...|.. .|..|.
Human   146 VLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFK-TDVS---KIVMELDTLEVADEDNS 206

  Fly   198 EFDDKGYMVRIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERK 262
            |..|.                   .|.:|                                  :.
Human   207 EISDS-------------------EDDSC----------------------------------KS 218

  Fly   263 ASGSSGHEPNDLLPMCPNRLESCVRQLLDDGIS---PFPYKVAKSMDPYMYRNIEFDCW--NDMR 322
            .:.::..:.|...|:..|      .||.::|.|   |...||.||::|.:|||:|::.|  :...
Human   219 KTAAAAADVNGFKPLSGN------EQLKNNGNSTSLPLSRKVLKSLNPAVYRNVEYEIWLKSKQA 277

  Fly   323 KEAKLYNVYINDYNFKVGAKCKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLH 387
            ::.:.|::... ..::||.||:|.|.:..:.....||.|..:..  .|.||.:||:..  .::|.
Human   278 QQKRDYSIAAG-LQYEVGDKCQVRLDHNGKFLNADVQGIHSENG--PVLVEELGKKHT--SKNLK 337

  Fly   388 PLPPD------------------------EYR-----------PWSLPFRYHRQMPRLPLP---- 413
            ..||:                        :||           |.:||       |||..|
Human   338 APPPESWNTVSGKKMKKPSTSGQNFHSDVDYRGPKNPSKPIKAPSALP-------PRLQHPSGVR 395

  Fly   414 KYAGKANKSSKWKKNKLFEMDQYF--EHSKCDLMPYMPVDNCYQGVHIQDDEQR----DHNDPEQ 472
            ::|..::.|.        ...|.|  ||......|...:.        :.|.:|    ||...|.
Human   396 QHAFSSHSSG--------SQSQKFSSEHKNLSRTPSQIIR--------KPDRERVEDFDHTSRES 444

  Fly   473 NDQNPTTEQRDREEPQAQKQHQ-----RTKASRVQPQNSSSSQNQEVSGSAAP------------ 520
            |....:.|  :|.|.||.::.:     :.:..:..|..||||.||..|.|:.|
Human   445 NYFGLSPE--ERREKQAIEESRLLYEIQNRDEQAFPALSSSSVNQSASQSSNPCVQRKSSHVGDR 507

  Fly   521 -------------------------------------------------------------PPTQ 524
                                                                         .|.:
Human   508 KGSRRRMDTEERKDKDSIHGHSQLDKRPEPSTLENITDDKYATVSSPSKSKKLECPSPAEQKPAE 572

  Fly   525 YM---NYVPMIPSRPGHLPPPWPASPMAI----AEEFPFPISGTPHPPP--------TEGCVYMP 574
            ::   |..|::.|...||.|..|:.|..:    :|...|..:|.|.|.|        |.|.....
Human   573 HVSLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAPIPVLSVTQTLTTGPDSAV 637

  Fly   575 FGGYGPPPPGAVALSGPH-PFMPLPSP------------PLNVTGIGE--PRRSLHPNGEDLPVD 624
            ...:..|.|..|::...: |.||||..            |.|..|...  |..||...|||||.|
Human   638 SQAHLTPSPVPVSIQAVNQPLMPLPQTLSLYQDPLYPGFPCNEKGDRAIVPPYSLCQTGEDLPKD 702

  Fly   625 MVTLRYFYNMGVDLH----WRMSHHTPPDELGMFGYHQ------------------QNNTDQQAG 667
            ...||:|:|:||..:    |....:       ::..||                  .|...|:|
Human   703 KNILRFFFNLGVKAYSCPMWAPHSY-------LYPLHQAYLAACRMYPKVPVPVYPHNPWFQEA- 759

  Fly   668 RTVVIGATEDNLTAVESTPP-----------PSPEVANATEQSPL----EKSAYAKRNLN-SVKV 716
               .....|.:.|..::..|           |.||:...|..|||    .:.:.:...|: ...:
Human   760 ---PAAQNESDCTCTDAHFPMQTEASVNGQMPQPEIGPPTFSSPLVIPPSQVSESHGQLSYQADL 821

  Fly   717 RGKRPEQL--QDIKDSLGPAAFLPTPTPSPSSNGSQFSFYTTPSPHHHLITPPRLLQPPPPPPIF 779
            ..:.|.||  .|.::||......|.|:..|:                     |.|...|..||.|
Human   822 ESETPGQLLHADYEESLSGKNMFPQPSFGPN---------------------PFLGPVPIAPPFF 865

  Fly   780 YH 781
            .|
Human   866 PH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	27/84 (32%)
		TUDOR	335..392	CDD:197660	16/56 (29%)
		TAF12	<446..>564	CDD:304643	35/206 (17%)
OTUD4	XP_011530342.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145151
Domainoid	1	1.000	67	1.000	Domainoid score	I9797
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8659
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870