Protein Alignment otu and OTUD4

DIOPT Version :10

• Sequence 1: NP_511089.2
• Gene: otu / 31789
• FlyBaseID: FBgn0003023
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_011530342.2
• Gene: OTUD4 / 54726
• HGNCID: 24949
• Length: 1121
• Species: Homo sapiens
• Alignment Length: 977
• Identity: 223/977 - (22%)
• Similarity: 348/977 - (35%)
• Gaps: 331/977 - (33%)

  Fly    11 SGSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFE 75
            :|.|:...|.|.||...|||||..|:|.|.|||.:|||:..:|..|.|:|:.|:.::...|..||
Human    16 AGPREDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFE 80

  Fly    76 KE-------IPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAEN 133
            ..       |.|.|:.|::.:..|:.:....|:.|:|.:||::.|:|...|:..|.|....:.|.
Human    81 AVTCNFKHFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEK 145

  Fly   134 FRVFFNNENHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFN-WDRFNV 197
            ..:.|:|.||:|.||.::|.|.:|:|||:.::|||:|:|| .|||   :|::...|.. .|..|.
Human   146 VLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFK-TDVS---KIVMELDTLEVADEDNS 206

  Fly   198 EFDDKGYMVRIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGRLEIKNQEERK 262
            |..|.                   .|.:|                                  :.
Human   207 EISDS-------------------EDDSC----------------------------------KS 218

  Fly   263 ASGSSGHEPNDLLPMCPNRLESCVRQLLDDGIS---PFPYKVAKSMDPYMYRNIEFDCW--NDMR 322
            .:.::..:.|...|:..|      .||.::|.|   |...||.||::|.:|||:|::.|  :...
Human   219 KTAAAAADVNGFKPLSGN------EQLKNNGNSTSLPLSRKVLKSLNPAVYRNVEYEIWLKSKQA 277

  Fly   323 KEAKLYNVYINDYNFKVGAKCKVELPNETEMYTCHVQNISKDKNYCHVFVERIGKEIVVPYESLH 387
            ::.:.|::... ..::||.||:|.|.:..:.....||.|..:..  .|.||.:||:..  .::|.
Human   278 QQKRDYSIAAG-LQYEVGDKCQVRLDHNGKFLNADVQGIHSENG--PVLVEELGKKHT--SKNLK 337

  Fly   388 PLPPD------------------------EYR-----------PWSLPFRYHRQMPRLPLP---- 413
            ..||:                        :||           |.:||       |||..|
Human   338 APPPESWNTVSGKKMKKPSTSGQNFHSDVDYRGPKNPSKPIKAPSALP-------PRLQHPSGVR 395

  Fly   414 KYAGKANKSSKWKKNKLFEMDQYF--EHSKCDLMPYMPVDNCYQGVHIQDDEQR----DHNDPEQ 472
            ::|..::.|.        ...|.|  ||......|...:.        :.|.:|    ||...|.
Human   396 QHAFSSHSSG--------SQSQKFSSEHKNLSRTPSQIIR--------KPDRERVEDFDHTSRES 444

  Fly   473 NDQNPTTEQRDREEPQAQKQHQ-----RTKASRVQPQNSSSSQNQEVSGSAAP------------ 520
            |....:.|  :|.|.||.::.:     :.:..:..|..||||.||..|.|:.|
Human   445 NYFGLSPE--ERREKQAIEESRLLYEIQNRDEQAFPALSSSSVNQSASQSSNPCVQRKSSHVGDR 507

  Fly   521 -------------------------------------------------------------PPTQ 524
                                                                         .|.:
Human   508 KGSRRRMDTEERKDKDSIHGHSQLDKRPEPSTLENITDDKYATVSSPSKSKKLECPSPAEQKPAE 572

  Fly   525 YM---NYVPMIPSRPGHLPPPWPASPMAI----AEEFPFPISGTPHPPP--------TEGCVYMP 574
            ::   |..|::.|...||.|..|:.|..:    :|...|..:|.|.|.|        |.|.....
Human   573 HVSLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAPIPVLSVTQTLTTGPDSAV 637

  Fly   575 FGGYGPPPPGAVALSGPH-PFMPLPSP------------PLNVTGIGE--PRRSLHPNGEDLPVD 624
            ...:..|.|..|::...: |.||||..            |.|..|...  |..||...|||||.|
Human   638 SQAHLTPSPVPVSIQAVNQPLMPLPQTLSLYQDPLYPGFPCNEKGDRAIVPPYSLCQTGEDLPKD 702

  Fly   625 MVTLRYFYNMGVDLH----WRMSHHTPPDELGMFGYHQ------------------QNNTDQQAG 667
            ...||:|:|:||..:    |....:       ::..||                  .|...|:|
Human   703 KNILRFFFNLGVKAYSCPMWAPHSY-------LYPLHQAYLAACRMYPKVPVPVYPHNPWFQEA- 759

  Fly   668 RTVVIGATEDNLTAVESTPP-----------PSPEVANATEQSPL----EKSAYAKRNLN-SVKV 716
               .....|.:.|..::..|           |.||:...|..|||    .:.:.:...|: ...:
Human   760 ---PAAQNESDCTCTDAHFPMQTEASVNGQMPQPEIGPPTFSSPLVIPPSQVSESHGQLSYQADL 821

  Fly   717 RGKRPEQL--QDIKDSLGPAAFLPTPTPSPSSNGSQFSFYTTPSPHHHLITPPRLLQPPPPPPIF 779
            ..:.|.||  .|.::||......|.|:..|:                     |.|...|..||.|
Human   822 ESETPGQLLHADYEESLSGKNMFPQPSFGPN---------------------PFLGPVPIAPPFF 865

  Fly   780 YH 781
            .|
Human   866 PH 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU_ALG13-like	21..149	CDD:438590	47/134 (35%)
		Tudor_TDRD13-like	336..389	CDD:410451	15/52 (29%)
OTUD4	XP_011530342.2	OTU_OTUD4	25..161	CDD:438615	47/135 (35%)
		Tudor_SF	282..341	CDD:470623	16/63 (25%)
		PHA03247	<550..893	CDD:223021	76/350 (22%)