DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and otud4

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_005174208.2	Gene:	otud4 / 327127	ZFINID:	ZDB-GENE-030131-5338	Length:	1363	Species:	Danio rerio

Alignment Length:	987	Identity:	216/987 - (21%)
Similarity:	351/987 - (35%)	Gaps:	325/987 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DMQVQRPITSGSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRF 66
            |.|.|   .:|.|......|:||.|.|.|||..|:|.|.|||.:|||:...|.||.::|..||.:
Zfish     9 DAQQQ---LAGDRTHESRMDEYLRSLGFYRKKIAKDGSCLFRAVAEQILHCQGLHTQVRAACVNY 70

  Fly    67 MTLKRRIFEKEIPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYA 131
            :...|..:|..|.|:|:.|::::..|:::....|:.|::.||:.:.|:::..:.....:....:.
Zfish    71 LRQNRPTYELFIEGNFEKYLENLQDPQSWVGQVEISALAELYKHDFIIFQEPDQPPVNLTENGFT 135

  Fly   132 ENFRVFFNNENHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFNWDRFN 196
            ...|:.|.|.||:||||...:.:.||:||||.::|||:::                       ..
Zfish   136 HKVRLCFLNGNHYDSVYPESFEKNAAVCQSILYELLYERV-----------------------CG 177

  Fly   197 VEFDDKGYMVRIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSINARKGGR-LEIKNQEE 260
            ||.:..|                     :|:                     |||| .:.::.||
Zfish   178 VERNVVG---------------------SCV---------------------KGGRGRDRQDSEE 200

  Fly   261 RKASGSSGHEPNDLLPMCPNRLESCVRQLLDDGISPFP-------------------YKVAKSMD 306
            .|:|..|..|.:|.....|       |:...:|::..|                   .||.||::
Zfish   201 CKSSEESELEEDDFWSTEP-------REKTSNGMNARPPQRGRGRGYSRGRGREFLSTKVQKSLN 258

  Fly   307 PYMYRNIEFDCW-NDMRKEAKLYNVYINDYNFKVGAKCKVELPNETEMYTCHVQNISKDKNYCHV 370
            |.:|||:|:|.| ...|.:.:..........:.||.||||:|.....:|:.:|:.:|.|.....|
Zfish   259 PTLYRNVEYDVWLRSKRLQQQRDFCIAAGMQYSVGDKCKVQLSGSNRLYSAYVKEVSPDNGPVTV 323

  Fly   371 FVERIGKEIVVPYESLHPLPPDEYRPW-----------------SLPFRYHRQMPRLPLPKYAGK 418
            |:|.:.|:..||..:|. ||.:|.:.|                 .:|..:..:..|.|....:..
Zfish   324 FIEELNKQQTVPLLNLR-LPSEEPQSWHTVSERGKRQAAPNNGAQIPSEWESRGGRRPNRMQSQS 387

  Fly   419 A-----NKSSKW--------KKNKLFEMDQYFEHSKCDLMPYMPVDNCYQGVHIQDDEQRDHNDP 470
            |     :|...|        .:||....||  ..|...::|    :...:.|.::...:.:||.|
Zfish   388 APSVRVHKQHSWPPQATTDDARNKFRRSDQ--RSSPVCILP----EEEEESVVLELLHKDEHNFP 446

  Fly   471 EQNDQNPTT----------EQRDREEPQAQKQHQRTKASR--VQPQNSSSSQNQEVSGSAAPPPT 523
            .......|.          |::...:.:.::....|:||:  :|.|.|.:.:...:..|..|.
Zfish   447 SLGPSPQTATPGEVIKKGGEKKSHRKKEQKENFMETEASQKPLQRQKSGTEEKHGIKFSEEPR-- 509

  Fly   524 QYMNYVPMIPSRPGHLPPPWPASPMAIAE---EFPFPISGTPHPPPTEGCVYMPFGGYGPPPPGA 585
                                ..|...|.|   |.|.|::.:                   ||..|
Zfish   510 --------------------QRSSSTINEKLQEKPIPVAAS-------------------PPSPA 535

  Fly   586 VALSGPHPFMPLPSPPLNVTGIGEPRRSL-----------------HPNGEDL-PVD-MVTLRYF 631
            :.||||.  .|:.|.  |.....:|.||.                 :|:...| ||. :.:|::.
Zfish   536 IFLSGPK--TPISSS--NSATSPDPNRSAPEAVKKATIQPKSSPAQNPDNSHLEPVSTLASLQHI 596

  Fly   632 YNMGVDLHWRMSHHTPPDELGMFGYHQQNNTDQQAGRTVVIGATEDNLTAVESTPPPSPEVANAT 696
            ..:.     .:|..||..:.                   :.||      |..|..||:.:..:||
Zfish   597 SRVA-----PVSETTPASQF-------------------ISGA------APVSVVPPASQSISAT 631

  Fly   697 EQSPLEKSAYAKRNLN---------------------------SVKVRGKRPEQLQDIKDSLGPA 734
            ..:|...||.|..:::                           :|.|....|:.:     |...|
Zfish   632 TPAPQSISAAAPVSVSTPASDSILVAAPDSATTPASQYIPGSRAVSVSTPAPQSI-----SGATA 691

  Fly   735 AFLPTPTPSPSSNGSQFSFYTTPSPHHHLITPPRLLQPPPPPPIFYHKAGPPQLGGAAQGQTPYA 799
            ....||||...|..:..| .|.|:||...:.....:..|.|..|              .|.|..|
Zfish   692 VSSNTPTPHSISRATAVS-VTAPAPHFTFVATAESISTPSPHSI--------------SGATAVA 741

  Fly   800 WGMPAPVVSPYEVINNYNMDPSAQ----------PQQQQPA------------TLQPAPLSVQSQ 842
              .|||:.|. ..:|  :..||.|          |:.:.|:            ||.|.|.|..:|
Zfish   742 --TPAPIQSA-PALN--STKPSFQMAQLPTVELLPRTEAPSQFTSVELVASQITLVPLPTSTPTQ 801

  Fly   843 ---------PAA 845
                     |||
Zfish   802 TTLAPTCPIPAA 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	26/77 (34%)
		TUDOR	335..392	CDD:197660	20/56 (36%)
		TAF12	<446..>564	CDD:304643	21/132 (16%)
otud4	XP_005174208.2	OTU	41..>120	CDD:327703	26/78 (33%)
		TUDOR	293..340	CDD:119391	16/46 (35%)
		Atrophin-1	<526..941	CDD:331285	74/366 (20%)
		Atrophin-1	793..>1141	CDD:331285	7/21 (33%)
		RAM	<1311..1355	CDD:317693
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578474
Domainoid	1	1.000	153	1.000	Domainoid score	I4268
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3486
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6497
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2026
SonicParanoid	1	1.000	-	-		X1801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.020