DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment otu and OTUD1

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_001138845.1	Gene:	OTUD1 / 220213	HGNCID:	27346	Length:	481	Species:	Homo sapiens

Alignment Length:	140	Identity:	34/140 - (24%)
Similarity:	62/140 - (44%)	Gaps:	8/140 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEKEIPGDFDSY 85
            |:||..|..||.|...|.:.|:|.:::.:|..|.||.|:|.:.|.::......|...|.||...:
Human   301 DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEF 365

  Fly    86 MQDMSKPKTYGTMTELRAMSCLYRRNVIL-----YEPYNMGTSVVF---NRRYAENFRVFFNNEN 142
            :...::...:....||.||..:...|:.|     .|...:.|.:.:   ......:..:.:.:..
Human   366 IIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNG 430

  Fly   143 HFDSVYDVEY 152
            |:|:|:|..|
Human   431 HYDAVFDHSY 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	20/82 (24%)
		TUDOR	335..392	CDD:197660
		TAF12	<446..>564	CDD:304643
OTUD1	NP_001138845.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..282
		Cys-loop	314..320		1/5 (20%)
		OTU	315..432	CDD:280496	22/116 (19%)
		His-loop	369..379		0/9 (0%)
		Variable-loop	426..431		0/4 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4984
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.650