DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment otu and AgaP_AGAP000835

DIOPT Version :9

Sequence 1:	NP_511089.2	Gene:	otu / 31789	FlyBaseID:	FBgn0003023	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_316803.5	Gene:	AgaP_AGAP000835 / 1277347	VectorBaseID:	AGAP000835	Length:	530	Species:	Anopheles gambiae

Alignment Length:	629	Identity:	182/629 - (28%)
Similarity:	276/629 - (43%)	Gaps:	158/629 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSRQAPDPYDQYLESRGLYRKHTARDASSLFRVIAEQMYDTQMLHYEIRLECVRFMTLKRRIFEK 76
            |.|:.||.||::|:..|.||||||.|.||||||::||.:..|..|.::|.:||.:|...:..|.|
Mosquito    14 GCRETPDIYDKFLQELGYYRKHTALDTSSLFRVVSEQQHGIQKYHEKVRKDCVMYMRSHKAQFVK 78

  Fly    77 EIPGDFDSYMQDMSKPKTYGTMTELRAMSCLYRRNVILYEPYNMGTSVVFNRRYAENFRVFFNNE 141
            :|...|::||.:||:.:|:||:.||:|::.||..||:|:||:......:.:......:|||:..:
Mosquito    79 DIKWGFEAYMNNMSRMRTHGTLLELKALALLYNANVLLFEPFAEAKWFLHSAANDTVWRVFYGRD 143

  Fly   142 NHFDSVYDVEYIERAAICQSIAFKLLYQKLFKLPDVSFAVEIMLHPHTFNWDRFNVEFDDKGYMV 206
            |||||:|..||:...|.||||.:.:||.|:..:|||.:|||.|||........::.  |::|..:
Mosquito   144 NHFDSIYTTEYMINMAECQSIVYDILYTKVLGVPDVQYAVERMLHDPDDTKTTYSE--DEEGRQI 206

  Fly   207 RIHCTDGRVFKLDLPGDTNCILENYKLCNFHSTNGNQSI-------NARKGGRLEIKNQEERKAS 264
            .. ..|||...|..|.:|.|:|....||:||::....:|       .:.:|.|:.|.....|.|.
Mosquito   207 AT-TEDGRQLVLSQPHETKCVLIYSHLCHFHNSTSFDAIQRFFAVYGSDEGYRVYIGPHVRRGAK 270

  Fly   265 GSSGHEPNDLLPMCPNRLESCVRQLLDDGISPFPYKVAKSMDPYMYRNIEFDCWNDMRKEAKLYN 329
            .|:        |:.|:...||||||||..|:||||||||::|..:|||:|||.|.::|.| |...
Mosquito   271 RSN--------PLLPDAKLSCVRQLLDMCITPFPYKVAKALDRNIYRNVEFDVWYEIRAE-KWSA 326

  Fly   330 VYINDYNFKVGAK----CKVELPNETEMYTCHVQNISKDK--NYCHVFVE-RIGKEI--VVPYES 385
            .::...|.:.|||    .|..:|:...|:..:.:...:.:  |..|.|:| .:.|::  :|..:.
Mosquito   327 FFLEMGNKEDGAKSIQDMKQIIPSGEIMHEGYRRGGERVRFANTQHPFIESTVVKDVTGIVSEQD 391

  Fly   386 -----LHPL----PPDEYRPWSLPFRYHRQMPRLPLPKYAGKANKSSKWKKNKLFEMDQYFEHSK 441
                 :||.    |.....|:.:|..|      ||.|...|..|..|.               ..
Mosquito   392 PSAQHVHPFGVADPHLTLAPYPMPQYY------LPSPDQYGSINTVSV---------------MA 435

  Fly   442 CDLMPYMPVDNCYQGVHIQDDEQRDHNDPEQNDQNPTTEQRDREEPQAQKQHQRTKASRVQPQNS 506
            ||                                            |||..:..|...:..|:
Mosquito   436 CD--------------------------------------------QAQLAYGDTNGQQPSPR-- 454

  Fly   507 SSSQNQEVSGSAAPPPTQYMNYVPMIPSRPGHLPPPWPASPMAIAEEFPFPISGTPHPPPTEGCV 571
                   :.|..         :.|:.|:....|..|:.            ||:|  |.|...||.
Mosquito   455 -------LGGCV---------FHPVYPTATTPLITPYA------------PIAG--HAPYIHGCF 489

  Fly   572 Y----------------MPF---GGYGPPPPGAVALSGPHPFMP 596
            |                :|:   ..|..|||     .|.:|:.|
Mosquito   490 YHCVQNGADANNPGTLAIPYDTSNPYNSPPP-----VGGNPYWP 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
otu	NP_511089.2	OTU	37..>115	CDD:303090	33/77 (43%)
		TUDOR	335..392	CDD:197660	16/74 (22%)
		TAF12	<446..>564	CDD:304643	13/117 (11%)
AgaP_AGAP000835	XP_316803.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I7580
eggNOG	1	0.900	-	-		E1_KOG2605
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I5198
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007272
OrthoInspector	1	1.000	-	-		mtm9733
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1801
TreeFam	1	0.960	-	-
	8	7.820