DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32152 and PRMT2

DIOPT Version :9

Sequence 1:	NP_001287079.2	Gene:	CG32152 / 317885	FlyBaseID:	FBgn0052152	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001526.2	Gene:	PRMT2 / 3275	HGNCID:	5186	Length:	433	Species:	Homo sapiens

Alignment Length:	339	Identity:	102/339 - (30%)
Similarity:	156/339 - (46%)	Gaps:	42/339 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 RVRSAGRIPAPPRKVPKELEDLD-RMTSADFRH-DTAARLDVMRNRQKDQAHMYFFQSVIHHQRH 209
            |....|.|||  ..|.|.:::.| ..|..|..: .:...|.:......||.....:.|||...:.
Human    72 RAGCCGYIPA--NHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKE 134

  Fly   210 LIKDRTILVLCCGTGTLALMAAQMGAKR-VYAVDYSKVTGYTTLVVRQNGYEGVITVMNGRMKDL 273
            .:.|:.||.:.||||.::|..|.....| ||||:.|::..:|..:|.|||:..:|||...:::|:
Human   135 SLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDV 199

  Fly   274 KLPTKVDGIICNWMGYCLLYESEILEVLEARDRWLKKGGFILPDLAALYLVASEEHKLKSERCNH 338
            .||.|||.::..|||.|||:|..|..:|.|||.|||:.|.|.|.:|||:||.....|....:...
Human   200 VLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLF 264

  Fly   339 WRNVYGFNMNAIRRYA-------------------LAEPCVALTTGKKLLTMAHCVLRLDLKRAR 384
            |.|.|.||::|::..|                   |:|||.              :|:||::..:
Human   265 WDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCT--------------ILQLDMRTVQ 315

  Fly   385 REDLFIDR-NIRLSVNREGYLECFLLFFEVQFSNSLNFKLSCNPCLKSPF--KSLWMQSVLFVEQ 446
            ..||...| .:|..:.:.|.|..|..:|.|.| .||............||  .:.|.|::..::.
Human   316 ISDLETLRGELRFDIRKAGTLHGFTAWFSVHF-QSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDD 379

  Fly   447 PFVMRKNIHYTGNL 460
            |..:......||::
Human   380 PVPVHTGDVVTGSV 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32152	NP_001287079.2	AdoMet_MTases	215..315	CDD:100107	44/100 (44%)
PRMT2	NP_001526.2	Interaction with ESR1	1..277		75/206 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3_PRMT2	34..86	CDD:212740	6/15 (40%)
		Interaction with RB1. /evidence=ECO:0000250	83..207		39/123 (32%)
		AdoMet_MTases	110..>169	CDD:302624	19/58 (33%)
		Interaction with ESR1	133..275		58/141 (41%)
		AdoMet_MTases	141..241	CDD:100107	44/99 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000206
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910