DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nxf3 and MEX67

DIOPT Version :9

Sequence 1:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_015156.1	Gene:	MEX67 / 855934	SGDID:	S000006090	Length:	599	Species:	Saccharomyces cerevisiae

Alignment Length:	426	Identity:	89/426 - (20%)
Similarity:	170/426 - (39%)	Gaps:	96/426 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 TDEFTTAIQEALRSRYEVDSRTLDLSRFHASPELSLHFCPLHMVKLLETVLVLSNHLFPH----- 231
            |.:..:.::..|..||:..::.|:|...|:.|||        :.|.:.:.:...:.:||.
Yeast   100 TSDTISFLRGVLLKRYDPQTKLLNLGALHSDPEL--------IQKGVFSSISTQSKMFPAMMKLA 156

  Fly   232 -------VTSLVLSNNYLCSLKAFAGNSQSFASLERLDISANRIQDLGELN-YINKL-SCKTIFL 287
                   |.|:.|::|.|..:.|.:..:|:|.:|:.|.::.|:|.....|. :.||. ..:.:.:
Yeast   157 STEKSLIVESVNLADNQLKDISAISTLAQTFPNLKNLCLANNQIFRFRSLEVWKNKFKDLRELLM 221

  Fly   288 AGNGLA--KLSVDVIRKMLPQ---LKNVHGCVQLGESTEAVDNIP-KSQQ-------LQGGGTNG 339
            ..|.:.  ||....:.::.|:   |.||  .|:..:..:.|.::| |.||       |....|
Yeast   222 TNNPITTDKLYRTEMLRLFPKLVVLDNV--IVRDEQKLQTVYSLPMKIQQFFFENDALGQSST-- 282

  Fly   340 LKFCQDFISSYYTFFDDTEERFKLKKYYDDQAMFSLSVPVQL----------NYVYGYKL-YNRN 393
                 ||.:::...:|:..|  :|...|..|:.||:||...:          ...:||.: .:||
Yeast   283 -----DFATNFLNLWDNNRE--QLLNLYSPQSQFSVSVDSTIPPSTVTDSDQTPAFGYYMSSSRN 340

  Fly   394 QKRQHSSFAQNAKLQVGRAALLLALSRLPLMHTDLENVGLDIQVFTSSLR-----IFTLTGYFKE 453
            ..:..|..:...:|.:|:.::......||.....|:....:..:.|.|..     :.||.|:|:|
Yeast   341 ISKVSSEKSIQQRLSIGQESINSIFKTLPKTKHHLQEQPNEYSMETISYPQINGFVITLHGFFEE 405

  Fly   454 -----------------------------ISSDTLEPRRFQRTFVLQTSNSPGWLITNDMLCITS 489
                                         .|::.|..:.|.||:|:...|: ..:|.:|:|.:.:
Yeast   406 TGKPELESNKKTGKNNYQKNRRYNHGYNSTSNNKLSKKSFDRTWVIVPMNN-SVIIASDLLTVRA 469

  Fly   490 TMPDPKKTIKF---KPETNMINTDPSVEKINKPAVT 522
            ......||...   :|.....:..|.|..:| |.:|
Yeast   470 YSTGAWKTASIAIAQPPQQQASVLPQVASMN-PNIT 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	8/39 (21%)
		PPP1R42	<192..296	CDD:411060	26/119 (22%)
		leucine-rich repeat	232..257	CDD:275382	8/24 (33%)
		leucine-rich repeat	258..281	CDD:275382	7/24 (29%)
		NTF2_like	338..489	CDD:415585	38/195 (19%)
MEX67	NP_015156.1	RRM_9	23..92	CDD:408240
		leucine-rich repeat	119..163	CDD:275382	9/51 (18%)
		PPP1R42	<155..256	CDD:411060	23/102 (23%)
		leucine-rich repeat	164..189	CDD:275382	8/24 (33%)
		leucine-rich repeat	190..217	CDD:275382	7/26 (27%)
		leucine-rich repeat	218..242	CDD:275382	3/23 (13%)
		TAP_C	537..597	CDD:197882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940