DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nxf3 and Nxf1

DIOPT Version :9

Sequence 1:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_067590.2	Gene:	Nxf1 / 59087	RGDID:	62014	Length:	618	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	110/457 - (24%)
Similarity:	196/457 - (42%)	Gaps:	53/457 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 RGQFLLDNLLSANRLKRLQEEVAVINTCQKIEVRVTPGLPKSMMCAQITDEFTTAIQEALRSRYE 188
            |.||.:::..:|:.||.:..::..... ::|.:.:....|..::..::..|....::..:..||:
  Rat   157 RAQFFVEDATTASALKAVNYKIQDREN-RRISIIINSSAPPYIVQNELKPEQVEQLKLIMSKRYD 220

  Fly   189 VDSRTLDLSRFHASPE---------LSLHFCPLHMVKLLETVLVLSNHLFPHVTSLVLSNNYLCS 244
            ...:.|||....:.|:         |:...|....::::|..:       |.:.||.||||.|..
  Rat   221 GSQQALDLKGLRSDPDLVAQNIDVVLNRRGCMAAALRIIEENI-------PELLSLNLSNNRLYK 278

  Fly   245 LKAFAGNSQSFASLERLDISANRIQDLGELNYINKLSCKTIFLAGNGLAKLSVD------VIRKM 303
            |...:...|...:|:.|::|.|.::...||:.|..|..:.::|..|.:....:|      .||:.
  Rat   279 LDDMSSIVQKAPNLKILNLSGNELKSEWELDKIKGLKLEELWLDRNPMCDTFLDQSTYISTIRER 343

  Fly   304 LPQLKNVHG---CVQLGESTEAVDNIPKSQQLQGGGTNGLKFCQDFISSYYTFFDDTEERFKLKK 365
            .|:|..:.|   ...:....||...:|..:....|..|.......|:..||..:|..:.:..|..
  Rat   344 FPKLLRLDGHELPPPIAFDVEAPTMLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDA 408

  Fly   366 YYDDQAMFSLSV------PVQLNYVYGYKLYN--RNQKRQHSSFAQNAKLQVGRAALLLALSRLP 422
            |:|. |..|||.      ||:.|..   |.:|  ||.|:...:..:...|:..|..::..|:.||
  Rat   409 YHDG-ACCSLSTPSNPQNPVRHNLA---KYFNDSRNVKKIKDTTTRFRLLKHTRLNVVAFLNELP 469

  Fly   423 LMHTDLENVGLDIQVFTSSLRIFTLTGYFKEI---SSDTLEPRRFQRTFVLQTSNSPGWLITNDM 484
            ..|.|:.:..:||...||:|..|::.|.|||:   |.|:|  |.|.|||:...:::.|..|.||.
  Rat   470 KTHHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSL--RAFTRTFIAVPASNSGLCIVNDE 532

  Fly   485 LCITSTMPDPKKTIKFKPETNMINTDPSVEKINKPAVTVLDRKSKEDVQISRPLSGKELNPLNKA 549
            |.:.:..|:         |.......|:....:.| |..|.::.::.:|.....||..|....|.
  Rat   533 LFVRNASPE---------EIQRAFAMPAPTPSSSP-VPTLSQEQQDMLQAFSTQSGMNLEWSQKC 587

  Fly   550 VQ 551
            :|
  Rat   588 LQ 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	7/48 (15%)
		PPP1R42	<192..296	CDD:411060	27/112 (24%)
		leucine-rich repeat	232..257	CDD:275382	9/24 (38%)
		leucine-rich repeat	258..281	CDD:275382	7/22 (32%)
		NTF2_like	338..489	CDD:415585	50/161 (31%)
Nxf1	NP_067590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113
		Interaction with ALYREF/THOC4 and LUZP4. /evidence=ECO:0000250\|UniProtKB:Q9UBU9	2..197		8/40 (20%)
		RNA-binding (RBD). /evidence=ECO:0000250	2..117
		Minor non-specific RNA-binding. /evidence=ECO:0000250	2..59
		Major non-specific RNA-binding. /evidence=ECO:0000250	60..117
		RNA binding. /evidence=ECO:0000250	60..117
		Nuclear localization signal. /evidence=ECO:0000250	66..99
		Nuclear export signal. /evidence=ECO:0000250	82..109
		Tap-RNA_bind	115..197	CDD:401194	8/40 (20%)
		leucine-rich repeat	223..265	CDD:275382	7/48 (15%)
		LRR_8	264..326	CDD:404697	20/61 (33%)
		LRR 1	265..290		9/24 (38%)
		leucine-rich repeat	266..291	CDD:275382	9/24 (38%)
		LRR 2	291..314		7/22 (32%)
		leucine-rich repeat	292..315	CDD:275382	7/22 (32%)
		LRR 3	315..342		4/26 (15%)
		leucine-rich repeat	316..346	CDD:275382	5/29 (17%)
		LRR 4	343..370		5/26 (19%)
		NTF2	381..537	CDD:238403	50/161 (31%)
		TAP_C	555..617	CDD:197882	9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020