Protein Alignment Nxf3 and NXF2

DIOPT Version :10

• Sequence 1: NP_729938.2
• Gene: Nxf3 / 317878
• FlyBaseID: FBgn0263232
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_071336.1
• Gene: NXF2 / 56001
• HGNCID: 8072
• Length: 626
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 116/519 - (22%)
• Similarity: 211/519 - (40%)
• Gaps: 82/519 - (15%)

  Fly   101 WVMMPIKVEI--------FNFKRSGPEDNMARGQFLLDNLLSANRLKRLQEEVAVINTCQKIEVR 157
            |:|..|:...        |::.|:       |..|.:.:..:|:.||.:..:: ..:..|||.:.
Human   139 WLMNSIQSHCSDRFTPVDFHYVRN-------RACFFVQDASAASALKDVSYKI-YDDENQKICIF 195

  Fly   158 VTPGL----------PKSMMCAQITDEFTTAIQEALRSRYEVDSRTLDLSRFHASPE-------- 204
            |....          |..|...::|          :..||.|..:.|||......|:
Human   196 VNHSTAPYSVKNKLKPGQMEMLKLT----------MNKRYNVSQQALDLQNLRFDPDLMGRDIDI 250

  Fly   205 -LSLHFCPLHMVKLLETVLVLSNHLFPHVTSLVLSNNYLCSLKAFAGNSQSFASLERLDISANRI 268
             |:...|....:|::|       ..||.:.||.|.||.|..|...:..::....::.|::|.|::
Human   251 ILNRRNCMAATLKIIE-------RNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKL 308

  Fly   269 QDLGELNYINKLSCKTIFLAGNGLA------KLSVDVIRKMLPQLKNVHG-------CVQLGEST 320
            :...||..:..|..:.::|.||.|.      ...|..||...|:|..:.|       .|.: :|:
Human   309 ESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDI-DSS 372

  Fly   321 EAVDNIPKSQQLQGGGTNGLK-FCQDFISSYYTFFDDTEERFKLKKYYDDQAMFSLSVPVQ---- 380
            |.:.  |..:...|..|  || ....|:..||:.:|..:.:..|..|: |:|.|||::|..
Human   373 ETMK--PCKENFTGSET--LKHLVLQFLQQYYSIYDSGDRQGLLGAYH-DEACFSLAIPFDPKDS 432

  Fly   381 -LNYVYGYKLYNRNQKRQHSSFAQNAKLQVGRAALLLALSRLPLMHTDLENVGLDIQVFTSSLRI 444
             .:.:..|...:||.|.....:.:...|:..:..::.:||.||....||.::.:|:...|..:..
Human   433 APSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLC 497

  Fly   445 FTLTGYFKEISSDTL-EPRRFQRTFVLQTSNSPGWLITNDMLCITSTMP-DPKKTIKFKPETNMI 507
            |::.|.|||:...:. ....|.|||:....:|....|.||.|.:....| :.:........|...
Human   498 FSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSS 562

  Fly   508 NTDPSVEKINKPAVTVLDRKSKEDVQISRP-LSGKELNPLNKAVQKMSLSQVD-HLPSENFNDM 569
            :::||:.:..:..|.....:|...::.|:. |...|.| ..:|.|..::.|.: .:|:|.|..:
Human   563 SSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWN-YTRAGQAFTMLQTEGKIPAEAFKQI 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_729938.2	leucine-rich repeat	191..231	CDD:275382	9/48 (19%)
		LRR	<229..>300	CDD:443914	20/76 (26%)
		leucine-rich repeat	232..257	CDD:275382	7/24 (29%)
		leucine-rich repeat	258..281	CDD:275382	5/22 (23%)
		NTF2_like	338..489	CDD:471850	41/157 (26%)
NXF2	NP_071336.1	Tap-RNA_bind	124..203	CDD:462696	14/71 (20%)
		PPP1R42	<227..363	CDD:455733	34/142 (24%)
		leucine-rich repeat	229..271	CDD:275382	9/48 (19%)
		LRR	<268..>332	CDD:443914	18/63 (29%)
		LRR 1	271..296		7/24 (29%)
		leucine-rich repeat	272..297	CDD:275382	7/24 (29%)
		LRR 2	297..320		5/22 (23%)
		leucine-rich repeat	298..321	CDD:275382	5/22 (23%)
		LRR 3	321..348		6/26 (23%)
		leucine-rich repeat	322..352	CDD:275382	7/29 (24%)
		LRR 4	349..376		6/27 (22%)
		NTF2_like	391..543	CDD:471850	39/152 (26%)
		TAP_C	570..623	CDD:197882	11/53 (21%)