DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nxf3 and Nxf3

DIOPT Version :9

Sequence 1:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_030107204.1	Gene:	Nxf3 / 245610	MGIID:	2685230	Length:	567	Species:	Mus musculus

Alignment Length:	616	Identity:	130/616 - (21%)
Similarity:	235/616 - (38%)	Gaps:	118/616 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QIFATFKSHEPDSRLIQNFKKHVNSQSPLDDLR------KNLNEKSKIREYVQELIGNEQQMGSV 60
            |.|....:|..|:.....:::...|..|:...|      .:..::..::::.|..:..|   |..
Mouse    22 QRFLNSPAHVSDTVHTSFYQQPAMSNPPMHTRRYTPYGIPSRYQRVSVQKWNQTDVNME---GGS 83

  Fly    61 LDTISSTEEDHRVATVTGWSTVNIANCAGVSNSSIFVALKWVM--------MPIKVEIFNFKRSG 117
            .......:.|.:..|...|..|.|.  .|:....     ||::        :|.....|::::
Mouse    84 KPPERKMQRDKQDDTSENWFKVTIP--FGIKYDK-----KWLLNLIQSQCSIPFTPVQFHYEK-- 139

  Fly   118 PEDNMARGQFLLDNLLSANRLKRLQEEVAVINTCQKIEVRVTP----------GLPKSMMCAQIT 172
                 .:..|.:||...|..||.:.::: :..|..||.:.::|          .|.|.......|
Mouse   140 -----MQAHFFVDNPNIAFMLKAISDKI-LDETDNKISIFISPCDEPHSVTELKLEKMDHTMLTT 198

  Fly   173 DEFTTAIQEAL-RSRYEVD----SRTLDLS---RFHASPELSLHFCPLHMVKLLETVLVLSNHLF 229
            ::.....|..| |.|...|    :|..||:   |.:.:|.||:|...:..|.....|..:
Mouse   199 NQQCATSQRVLNRQRLPFDQDLMTRPTDLALVPRRYMTPSLSIHKEDMTQVNSEGEVAKV----- 258

  Fly   230 PHVTSLVLSNNYLCSLKAFAGNSQSFASLERLDISANRIQDLGELNYINKLSCKTIFLAGNGLAK 294
             |...|    ..:|:       .||..|....|.|:|       :|.|.:|..|.:.|.|....|
Mouse   259 -HAPDL----EKICA-------DQSSLSTTMPDKSSN-------INSILELFPKLLSLDGQESHK 304

  Fly   295 LSVDVIRKMLPQL------KNVHGCVQLGESTEAVDNIPKSQQLQGGGTNGLKFCQDFISSYYTF 353
                      |.|      |.:..|.::...:|::    |:..||            |:..||..
Mouse   305 ----------PTLCGPEDHKTLSACKEIFFGSESI----KTMVLQ------------FLKQYYFI 343

  Fly   354 FDDTEERFKLKKYYDDQAMFSLSVP-----VQLNYVYGYKLYNRNQKRQHSSFAQNAKLQVGRAA 413
            :|:.:.:..|..|: .:|.|:|::|     :.:|.:..|..::||.|.....:.:...|:..:..
Mouse   344 YDNGDRQGLLNAYH-PEACFTLTIPFSSIDLSMNSLCEYFKFSRNMKILKDPYMRRQLLKHKKCD 407

  Fly   414 LLLALSRLPLMHTDLENVGLDIQVFTSSLRIFTLTGYFKEISSDTLE-PRRFQRTFVLQTSNSPG 477
            ::..|..||....||.:..:||.:.|..:..|:::|.|||:.:.... ...|.|.||:...||..
Mouse   408 IIHFLRTLPKTQHDLTSFVVDICLQTEKMLCFSVSGLFKEVDNSAQGCMHAFTRIFVVTHDNSSE 472

  Fly   478 WLITNDMLCITSTMPDPKKTIKFKPETNMINTDPSVEKINKPAVTVLDRKSKEDVQIS-RPLSGK 541
            ..|.||.|.:|:....|..:...  .|:..:..||..:..:..|.....:|..:|..| :.|...
Mouse   473 LCIINDKLSVTNVHEVPSASTPV--ATSSTSYLPSFSQDQQEMVPTFCAQSGVNVDRSQKSLHDD 535

  Fly   542 ELNPLNKAVQKMSLSQV-DHLPSENFNDMPP 571
            :.| .|:|:|.::|.:| |.:..:.|....|
Mouse   536 QWN-YNRAIQSLALLKVEDTISEDKFTQTDP 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	10/42 (24%)
		PPP1R42	<192..296	CDD:411060	26/106 (25%)
		leucine-rich repeat	232..257	CDD:275382	4/24 (17%)
		leucine-rich repeat	258..281	CDD:275382	5/22 (23%)
		NTF2_like	338..489	CDD:415585	39/156 (25%)
Nxf3	XP_030107204.1	Tap-RNA_bind	99..181	CDD:370331	18/99 (18%)
		leucine-rich repeat	206..244	CDD:275382	12/44 (27%)
		leucine-rich repeat	263..293	CDD:275382	7/29 (24%)
		NTF2_like	328..484	CDD:385413	35/161 (22%)
		TAP_C	499..561	CDD:197882	14/62 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020