DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nxf3 and nxf-2

DIOPT Version :9

Sequence 1:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_506568.2	Gene:	nxf-2 / 179938	WormBaseID:	WBGene00003835	Length:	405	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	83/345 - (24%)
Similarity:	152/345 - (44%)	Gaps:	37/345 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 IQEALRSRYEVDSRTLDLSRFHASPEL---SLHFCPLHMVKLLETVLVLSNHLFPHVTSLVLSNN 240
            :|:.:...|......|:||.|..:.|.   .:..| |...:::..||....:.:|.::.:..|||
Worm    43 VQDVVDGCYVATDDVLNLSNFSKNTEFVERDMLMC-LTKTRVMSVVLQHIGYKYPRISGISFSNN 106

  Fly   241 YLCSLKAFAGNSQSFASLERLDISANRIQDLGELNYINKLSCKTIFLAGNGLAKLSV------DV 299
            .||.|...:..|.....|:.||:|.|:|....||..:..:..:|:|..||.:.:..|      :.
Worm   107 RLCHLDHLSSLSSISKFLKFLDLSHNQISSGEELKKLGTIPVETVFFEGNPVCEKFVQCAEYANF 171

  Fly   300 IRKMLPQLKNVHGC-VQLGESTEAVDNIPKSQQLQGGGTNGLKFCQDFISSYYTFFDDT---EER 360
            |:|..|:..|:.|. |:.......::.|...:....|........::||.:||..:|..   :.|
Worm   172 IQKTFPKCSNLDGMEVEPKPDHNRIEQIIPFRNGYYGSDEVRTLVEEFIITYYKIYDGADGQQTR 236

  Fly   361 FKLKKYYD-DQAMFSLSV-----PVQLNYVY----GYKLYNRNQKR--QHSSFAQN--AKLQVGR 411
            .:|...|| :.:.|:.:|     |::. .:|    .|::|.|....  ....||.|  :::..|.
Worm   237 KQLLDAYDTNNSTFTHTVVCLWDPIKF-VMYPDSESYRMYLRTSHNVLNQEYFAANRASRISHGA 300

  Fly   412 AALLLALSRLPLMHTDLENVGLDIQVFTSSLRIFTLTGYFKEISSDTLEPRR-------FQRTFV 469
            ..:::||||||.....::...:|:.:.:::|..|||.|.|:: ....::|..       |.|||:
Worm   301 MDIVVALSRLPATIHLMDTFVVDVFLVSATLLGFTLHGTFRD-GPSAIKPENTEEHDNYFTRTFM 364

  Fly   470 LQTSNSPGWLITNDMLCITS 489
            :.........|.:|.|.|:|
Worm   365 VAPRGEGKVAIVSDQLFISS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	9/42 (21%)
		PPP1R42	<192..296	CDD:411060	29/106 (27%)
		leucine-rich repeat	232..257	CDD:275382	7/24 (29%)
		leucine-rich repeat	258..281	CDD:275382	8/22 (36%)
		NTF2_like	338..489	CDD:415585	42/174 (24%)
nxf-2	NP_506568.2	leucine-rich repeat	55..97	CDD:275382	9/42 (21%)
		leucine-rich repeat	98..123	CDD:275382	7/24 (29%)
		leucine-rich repeat	124..147	CDD:275382	8/22 (36%)
		leucine-rich repeat	148..178	CDD:275382	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159790
Domainoid	1	1.000	67	1.000	Domainoid score	I6424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950