DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nxf3 and NXF1

DIOPT Version :9

Sequence 1:	NP_001287064.2	Gene:	Nxf3 / 317878	FlyBaseID:	FBgn0263232	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_006353.2	Gene:	NXF1 / 10482	HGNCID:	8071	Length:	619	Species:	Homo sapiens

Alignment Length:	464	Identity:	108/464 - (23%)
Similarity:	192/464 - (41%)	Gaps:	67/464 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 RGQFLLDNLLSANRLKRLQEEVAVINTCQKIEVRVTPGLPKSMMCAQITDEFTTAIQEALRSRYE 188
            |.||.:::..:|:.||.:..:: :....::|.:.:....|...:..::..|....::..:..||:
Human   158 RAQFFVEDASTASALKAVNYKI-LDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYD 221

  Fly   189 VDSRTLDLSRFHASPE---------LSLHFCPLHMVKLLETVLVLSNHLFPHVTSLVLSNNYLCS 244
            ...:.|||....:.|:         |:...|....::::|..:       |.:.||.||||.|..
Human   222 GSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENI-------PELLSLNLSNNRLYR 279

  Fly   245 LKAFAGNSQSFASLERLDISANRIQDLGELNYINKLSCKTIFLAGNGLA------KLSVDVIRKM 303
            |...:...|...:|:.|::|.|.::...||:.|..|..:.::|.||.|.      ...:..||:.
Human   280 LDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRER 344

  Fly   304 LPQLKNVHG---CVQLGESTEAVDNIPKSQQLQGGGTNGLKFCQDFISSYYTFFDDTEERFKLKK 365
            .|:|..:.|   ...:....||...:|..:....|..|.......|:..||..:|..:.:..|..
Human   345 FPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDA 409

  Fly   366 YYDDQAMFSLSVPV-----QLNYVYGYKLYNRNQKRQHSSFAQNAKLQVGRAALLLALSRLPLMH 425
            |:|. |..|||:|.     ..:.:..|...:||.|:......:...|:..|..::..|:.||...
Human   410 YHDG-ACCSLSIPFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQ 473

  Fly   426 TDLENVGLDIQVFTSSLRIFTLTGYFKEI---SSDTLEPRRFQRTFVLQTSNSPGWLITNDMLCI 487
            .|:.:..:||...||:|..|::.|.|||:   |.|:|  |.|.|||:...:::.|..|.||.|.:
Human   474 HDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSL--RAFTRTFIAVPASNSGLCIVNDELFV 536

  Fly   488 TS----------TMPDPKKTIKFKPETNMINTDPSVEKINKPAVTVLDRKSKEDVQISRPLSGKE 542
            .:          .||.|      .|.::.:.|              |..:.:|.:|.....||..
Human   537 RNASSEEIQRAFAMPAP------TPSSSPVPT--------------LSPEQQEMLQAFSTQSGMN 581

  Fly   543 LNPLNKAVQ 551
            |....|.:|
Human   582 LEWSQKCLQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nxf3	NP_001287064.2	leucine-rich repeat	191..231	CDD:275382	7/48 (15%)
		PPP1R42	<192..296	CDD:411060	29/118 (25%)
		leucine-rich repeat	232..257	CDD:275382	9/24 (38%)
		leucine-rich repeat	258..281	CDD:275382	7/22 (32%)
		NTF2_like	338..489	CDD:415585	46/158 (29%)
NXF1	NP_006353.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85
		RNA-binding (RBD)	2..118
		Minor non-specific RNA-binding	2..60
		Major non-specific RNA-binding	61..118
		Nuclear localization signal	67..100
		Nuclear export signal	83..110
		Tap-RNA_bind	116..198	CDD:401194	8/40 (20%)
		noncanonical RNP-type RNA-binding (RBD) domain	121..198		8/40 (20%)
		leucine-rich repeat (LRR) domains	199..371		39/178 (22%)
		LRR	<200..>327	CDD:227223	31/133 (23%)
		leucine-rich repeat	224..266	CDD:275382	7/48 (15%)
		LRR_8	265..327	CDD:404697	21/61 (34%)
		leucine-rich repeat	267..292	CDD:275382	9/24 (38%)
		leucine-rich repeat	293..316	CDD:275382	7/22 (32%)
		leucine-rich repeat	317..347	CDD:275382	6/29 (21%)
		NTF2	382..538	CDD:238403	46/158 (29%)
		TAP_C	556..618	CDD:197882	9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1051093at2759
OrthoFinder	1	1.000	-	-		FOG0000862
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020