DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32121 and BtbVII

DIOPT Version :9

Sequence 1:	NP_001097599.1	Gene:	CG32121 / 317867	FlyBaseID:	FBgn0052121	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	186/760 - (24%)
Similarity:	281/760 - (36%)	Gaps:	232/760 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SQQQFCLRWHNHQTSLLSTLPILLDQSHLTDVTISAEGRQLRAHRVVLSACSSFFMDIFRALEAS 90
            |.|||||||:|||.:.:|....||....|.|||::||||||:||::|||||||:|..:| .....
  Fly     2 SVQQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALF-TTNPC 65

  Fly    91 NHPVIIIPGASFGAIVSLLTFMYSGEVNVYEEQIPMLLNLAETLGIKGLADVQNNNLPKTARSGG 155
            .||::|:....:..:.:::.|||.|||||.:||:|.:|..||.|.|||||
  Fly    66 QHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLA--------------- 115

  Fly   156 GSYMDTTNEKSSEFERPTTPSPTPTPTLTPSHTPTPSHSLPLPQLPSAALNTPLLANKLGSVNSS 220
                          |.||.|:     .||.|.:.:.:....:  :..|.:.|. ..|..||: .:
  Fly   116 --------------EMPTDPA-----NLTKSDSKSSTDGTEM--VGGAGVGTG-AGNSAGSL-GA 157

  Fly   221 GMGTTPLENLFKSLQFYPSLLPQPLNFSQTALNKTTELLAKYQQQCQLYQSGMQEDQ-------- 277
            |.|::..::|:.|.:.......|    .|.|..:..:....:|||.||.|...|..|
  Fly   158 GSGSSVGDSLWSSSEAQQFQQQQ----QQQAQQQAQQQHHHHQQQQQLQQQQQQAQQQQQQQQHH 218

  Fly   278 --------------LETDCFGSKRL-----KGDSPPKELRRLEKSLLKNPKSSSTTNSSSSKSPQ 323
                          .:|.....:|.     .|.||....:||.|         |:.|.|..::..
  Fly   219 HHHHQQQQSGQAQAAQTHHHQMRRTPSPLSAGTSPATRRKRLRK---------SSNNGSGDRNNA 274

  Fly   324 ECSNPNPIVATSPVTLAPPTMAHFSP------------QLPVVKCSSASYPSAL----------- 365
            |..:.:.:.|.|....|..::|..:.            .|...|....|..:.|
  Fly   275 EEQHNSSLDAGSGAGNAGLSLAQMNQMTFGAGGGLAGHSLHAAKLLKESASAELEQQPQDSDLDD 339

  Fly   366 GQGQLYSS-KP-----------PL-YSAAVTPTA--AQQAAQMHHHPQPGPSPYISAEDHAKLQL 415
            |.|.|:.. ||           || .|...||:.  |..:...|..|.|..:|:   ..|..|
  Fly   340 GHGHLHMQIKPEVDIGGVNQTMPLDISGGTTPSEHDAPNSQSSHSEPSPAHAPH---PPHPPL-- 399

  Fly   416 HIEQYQREAAAAAAAAAGGM----------ALVSAKSEP-----NLLSLSADRDKSLATAP-IKP 464
                      .||::::||.          .:.|.:.:|     :...:...|::.|...| :|.
  Fly   400 ----------GAASSSSGGSGSFERSFSIGGVGSVECDPDGTPSSPAVMGTKRNRVLTRQPRVKR 454

  Fly   465 PSNSKLYATCFICHKQLS----------NQYNLRVHLETHQNVRYACNVCSHVSRSKDALRKHVS 519
            .|:| :.:|     .|:|          :.:|...  .|....|......||....:.|:..|..
  Fly   455 DSDS-ISST-----NQISPDTAATTLDFDPFNAAG--ATSATARDYSTTGSHHLHHQSAVHHHHH 511

  Fly   520 Y--------RHPGAPSPCENEARRKRVSKLAATT-----VPTSTPM-----------SMSASHTV 560
            .        ||...|:|           .||.:|     ||:|||.           ..||.|..
  Fly   512 LLTVPPRIERHASEPAP-----------SLAPSTPHLLSVPSSTPYLIKQHSDPLLPRQSALHMA 565

  Fly   561 TSGDVGPAPATTLGCSGQEARNPYLFLPNQFQ--MAAAAAA------------VAVAESSPASGQ 611
            .||. |.:.|...|      .||:..|..|:.  ::.:.|:            :::.||..|||.
  Fly   566 GSGS-GSSSAMATG------SNPFAPLHRQYSHPLSGSNASYVTPAPLHHPHHISLPESIYASGS 623

  Fly   612 PS--------LDLAHEAPPSIKSE--REPPTASNGEATGVEASAS 646
            |.        :.....|.|.:.||  ..|..||.|.::.|.|:.|
  Fly   624 PPPAGSSQYLVPTRVVACPVVSSETAATPTNASPGSSSTVSAAVS 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32121	NP_001097599.1	BTB	48..142	CDD:279045	46/93 (49%)
		BTB	56..149	CDD:197585	43/92 (47%)
		C2H2 Zn finger	474..494	CDD:275370	3/29 (10%)
		C2H2 Zn finger	501..518	CDD:275370	3/16 (19%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	46/122 (38%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	43/114 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020