DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32112 and ABHD18

DIOPT Version :9

Sequence 1:	NP_001261779.1	Gene:	CG32112 / 317860	FlyBaseID:	FBgn0052112	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001345383.1	Gene:	ABHD18 / 80167	HGNCID:	26111	Length:	479	Species:	Homo sapiens

Alignment Length:	513	Identity:	234/513 - (45%)
Similarity:	321/513 - (62%)	Gaps:	66/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKLDSIYRRMLITRFFEKGWGKPENLRKVFQFRKVISSRESCFKLVPRDYPVEITKKEIGAESTL 67
            ||||.:|||:|:|:.|.:|||:||:|:::|:|||:|.:||.|..||..||||.|.|.|..::..:
Human     4 SKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKIEEQSDCKI 68

  Fly    68 IEGQFKTPMELHMPGVVPEESQQAH---------------FQLLIPNKWKNEKHKPICIHLAGTG 117
            ::|.|.:||..::|.::|.||..|.               ||.::|.:| |.|::|:||||||||
Human    69 LDGHFVSPMAHYVPDIMPIESVIARIIDEMLDTNLILLPLFQFIVPKEW-NSKYRPVCIHLAGTG 132

  Fly   118 DHFFWRRRNFIAKPLLKDANIGSIILENPFYGLRKPNNQTRSNLHNVSDIFVMGGCLILECLVLF 182
            ||.:||||..:|:|::|:|.:.|::||||:||.|||.:|.||:|.||||:|||||.|:||...|.
Human   133 DHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALL 197

  Fly   183 HWCERNGFGPLGVTGLSMGGHMASLAATNWPKPLVLVPCLSWSTASAVFTTGVMSQSINWDMLET 247
            ||.||.|:||||:||:||||||||||.:|||||:.|:|||||||||.||||||:|:||||..||.
Human   198 HWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLSKSINWRELEK 262

  Fly   248 QYFSDGQYRERLSKMVTVI-DDAFSAGQSFIQNFNQSLQELKE----------DISD---TRKIH 298
            ||::...|.|.:..|:... .|:|..||.|:::|..|..:|..          |||:   ::|..
Human   263 QYYTQTVYEEEIIHMLEYCGTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPA 327

  Fly   299 ATENSNTCGDKYETQGICPQEDSSIFLSKSLKNTKLDSENLTIDAKDALSQKVAIETEETSKDSG 363
            ...||:.......::|:..|:.|           |:...|.|:               .|:| ||
Human   328 DCHNSSKTSVSATSEGLLLQDTS-----------KMKRFNQTL---------------STNK-SG 365

  Fly   364 STLTNLMKFILPLSAQSKTDKIDITKTNWWEREALQFMRGMMDECTHLKNFSVPFDTSLIIAVCA 428
            .|..|...:.|....||:         |...:|:|.||:|:||||||:.|||||.|.||||.|.|
Human   366 YTSRNPQSYHLLSKEQSR---------NSLRKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQA 421

  Fly   429 KDDAYVPREGCSSLEEIWPGAEVRYLDAGHVSAYVLHQKLFRSCIIEAFERAKKIYEN 486
            |:|||:||.|..||:|||||.|:|||:.||:|||:..|.|||..|.:||:|....|.|
Human   422 KEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQAIYDAFDRFLHKYAN 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32112	NP_001261779.1	DUF2048	15..479	CDD:286795	223/492 (45%)
ABHD18	NP_001345383.1	DUF2048	16..472	CDD:286795	223/492 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155636
Domainoid	1	1.000	391	1.000	Domainoid score	I786
eggNOG	1	0.900	-	-		E1_KOG1551
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H105457
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1887
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60068
OrthoDB	1	1.010	-	-		D1294532at2759
OrthoFinder	1	1.000	-	-		FOG0005846
OrthoInspector	1	1.000	-	-		oto89909
orthoMCL	1	0.900	-	-		OOG6_105322
Panther	1	1.100	-	-	LDO	PTHR13617
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3734
SonicParanoid	1	1.000	-	-		X4239
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800