DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32026 and IDH1

DIOPT Version :9

Sequence 1:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_014361.1	Gene:	IDH1 / 855691	SGDID:	S000004982	Length:	360	Species:	Saccharomyces cerevisiae

Alignment Length:	345	Identity:	138/345 - (40%)
Similarity:	217/345 - (62%)	Gaps:	13/345 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 KASGEPRVITLMPGDGIGPEISMAVIKILEAAKTPLIFEPVDVTPVLNSQGMTSVPEQVIESMNR 441
            |..|....:||:||||:|.||:.:|..|.||...|:.:|.:::....:.:|:    .:.:||:.|
Yeast    23 KKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGV----YEAVESLKR 83

  Fly   442 TKVGLKGPLMTPVG-TGFRSLNLTLRQLFNLYANIRPCRSLPGVETVYGDVDIVTIRENTEGEYS 505
            .|:||||...||.. ||..|||:.||:..::|||:...:||.||:|...|:|::.||||||||:|
Yeast    84 NKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFS 148

  Fly   506 GIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAMKRKKVTAVAESQVMRMSDGLFLRCVREMA 570
            |:||..|.|||:|:|::||..:.|:|.:.|.:|....||.||||.::.:|::.||||...:.|:.
Yeast   149 GLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIG 213

  Fly   571 AKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYDMLVLPNLYGDIISDTCAGLIGGLGLTPSGNV 635
            .|....:|.:.|..:.::|..|.     .|.::|:||.|::||.|:.:..|.||||.||....|.
Yeast   214 QKEYPDIDVSSIIVDNASMQAVA-----KPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANF 273

  Fly   636 GTNGAIFE--SVHGTAPDIAGKDLANPTALLLSSVMMLHYIGLHEHADKIEKAVLKTIRDDNIRT 698
            |.:.|:||  |.| ...||.|:::|||||::|||.:||:::||:|:|.:|.|||.:||.:....|
Yeast   274 GRDYAVFEPGSRH-VGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTT 337

  Fly   699 MDLGGKAKCSEYTDALIKNL 718
            .|:||.:..:::|:.:|..|
Yeast   338 RDIGGSSSTTDFTNEIINKL 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	135/338 (40%)
IDH1	NP_014361.1	mito_nad_idh	26..357	CDD:272942	136/340 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X402
TreeFam	0	0.000	Not matched by this tool.
	4	3.810