DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32026 and LEU2

DIOPT Version :9

Sequence 1:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_009911.2	Gene:	LEU2 / 850342	SGDID:	S000000523	Length:	364	Species:	Saccharomyces cerevisiae

Alignment Length:	381	Identity:	106/381 - (27%)
Similarity:	173/381 - (45%)	Gaps:	67/381 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 PRVITLMPGDGIGPEISMAVIKILEA-----AKTPLIFE-------PVDVTPVLNSQGMTSVPEQ 434
            |:.|.::|||.:|.||:...||:|:|     :.....||       .:|.|.|       .:|::
Yeast     4 PKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGV-------PLPDE 61

  Fly   435 VIESMNRTKVGLKGPLMTPV-GTGFRSLN-----LTLRQLFNLYANIRPCR-------SLPGVET 486
            .:|:..:....|.|.:..|. |||  |:.     |.:|:...||||:|||.       .|..::.
Yeast    62 ALEASKKADAVLLGAVGGPKWGTG--SVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKP 124

  Fly   487 VYG-DVDIVTIRENTEGEY---------SGIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAM 541
            .:. ..|.|.:||...|.|         .|:........|..::.|||.|:....::.....: .
Yeast   125 QFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPI-W 188

  Fly   542 KRKKVTAVAESQVMRMSDGLFLRCVREMAAKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYD-M 605
            ...|...:|.|::.|       :.|.|..     |.:...:|.:...:.:..:.:|::|...: :
Yeast   189 SLDKANVLASSRLWR-------KTVEETI-----KNEFPTLKVQHQLIDSAAMILVKNPTHLNGI 241

  Fly   606 LVLPNLYGDIISDTCAGLIGGLGLTPSGNV------GTNGAIFESVHGTAPDIAGKDLANPTALL 664
            ::..|::||||||..:.:.|.|||.||.::      .|...::|..||:|||:. |:..||.|.:
Yeast   242 IITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLP-KNKVNPIATI 305

  Fly   665 LSSVMMLHY-IGLHEHADKIEKAVLKTIRDDNIRTMDLGGKAKCSEYTDALIKNLK 719
            ||:.|||.. :.|.|....||.|| |.:.|..|||.||||....:|..||:.:.:|
Yeast   306 LSAAMMLKLSLNLPEEGKAIEDAV-KKVLDAGIRTGDLGGSNSTTEVGDAVAEEVK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	105/378 (28%)
LEU2	NP_009911.2	leuB	6..359	CDD:272939	104/376 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S361
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.720