DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32026 and Idh3a

DIOPT Version :9

Sequence 1:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_083849.1	Gene:	Idh3a / 67834	MGIID:	1915084	Length:	366	Species:	Mus musculus

Alignment Length:	356	Identity:	208/356 - (58%)
Similarity:	264/356 - (74%)	Gaps:	15/356 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 QGQKGGAGGKSGKASGEPRVITLMPGDGIGPEISMAVIKILEAAKTPLIFEPVDVTPVLNSQGMT 429
            |..:|.|||        .:.:||:||||||||||.:|:||.:|||.|:.:|..:||.:....|..
Mouse    22 QVTRGFAGG--------VQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKW 78

  Fly   430 SVPEQVIESMNRTKVGLKGPLMTPVGTGFRSLNLTLRQLFNLYANIRPCRSLPGVETVYGDVDIV 494
            .:|.:..|||::.|:||||||.||:..|..|:||.||:.|:||||:|||.|:.|.:|.|.||:||
Mouse    79 MIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIV 143

  Fly   495 TIRENTEGEYSGIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAMKRKKVTAVAESQVMRMSD 559
            |||||||||||||||.:|:||||||||||..||.|:||:.|:||....|..||||.::.:|||||
Mouse   144 TIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208

  Fly   560 GLFLRCVREMAAKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYDMLVLPNLYGDIISDTCAGLI 624
            ||||:..||:|...|.      ||:.|..:.|||||:||||.::|:||:|||||||:||.|||||
Mouse   209 GLFLQKCREVAENCKD------IKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLI 267

  Fly   625 GGLGLTPSGNVGTNG-AIFESVHGTAPDIAGKDLANPTALLLSSVMMLHYIGLHEHADKIEKAVL 688
            ||||:|||||:|.|| |||||||||||||||||:|||||||||:||||.::||.:||.|||.|..
Mouse   268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACF 332

  Fly   689 KTIRDDNIRTMDLGGKAKCSEYTDALIKNLK 719
            .||:|....|.||||.||||::|:.:.:.:|
Mouse   333 ATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	202/336 (60%)
Idh3a	NP_083849.1	mito_nad_idh	29..362	CDD:272942	204/346 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S361
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100541
Panther	1	1.100	-	-	O	PTHR11835
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X402
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.660