Protein Alignment CG32026 and IDH2

DIOPT Version :9

• Sequence 1: NP_729420.1
• Gene: CG32026 / 317829
• FlyBaseID: FBgn0052026
• Length: 719
• Species: Drosophila melanogaster
• Sequence 2: NP_002159.2
• Gene: IDH2 / 3418
• HGNCID: 5383
• Length: 452
• Species: Homo sapiens
• Alignment Length: 480
• Identity: 102/480 - (21%)
• Similarity: 173/480 - (36%)
• Gaps: 130/480 - (27%)

  Fly   320 TGSTPPQKPTKSSKPPNKPPAGPGKKSASKPPTASKPPVKSPAGGQGQKGGAGGKSGKASGEPRV 384
            :||.|...|...:.|.::..  |.:..|.|....:||.|:
Human    15 SGSRPAWAPAALTAPTSQEQ--PRRHYADKRIKVAKPVVE------------------------- 52

  Fly   385 ITLMPGDGIGPEISMAVIKILEAAKTPLIFEPVDVTPVLNSQGMTS---VPEQV-IESMNRTK-- 443
               |.||    |::..:.:.:   |..||...||:.......|:.:   ..:|| |:|...|:
Human    53 ---MDGD----EMTRIIWQFI---KEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKY 107

  Fly   444 -VGLKGPLMTP---------VGTGFRSLNLTLRQLFNLYANIRP--CRSLPGVETVYGDVDIVTI 496
             |.:|...:||         :...::|.|.|:|.:........|  |:::|  ..|.|....:||
Human   108 SVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIP--RLVPGWTKPITI 170

  Fly   497 RENTEGEY-----------------------SGI-EHTLVNGVVQSIKLITRNASLRVAEYT--- 534
            ..:..|:.                       ||: |..:.|.....:.:...|....::.:.
Human   171 GRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSC 235

  Fly   535 FQYALAMKRKKVTAVAESQVMRMSDGLFLRCVREMAAK-YKSKMDQAGIKYEESTMTTVCLNIVQ 598
            ||||: .|:..:....::.:::..||.|....:|:..| ||:..|:..|.||...:..:...:::
Human   236 FQYAI-QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLK 299

  Fly   599 DP-------KRYDMLVLPNLYGDIISDTCAGLIGGLGLTPSGNVGTNGAIF--ESVHGTA----- 649
            ..       |.||        ||:.||..|...|.|||..|..|..:|...  |:.|||.
Human   300 SSGGFVWACKNYD--------GDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR 356

  Fly   650 PDIAGKDLA-NPTALLLSSVMMLHYIG-------LHEHADKIEKAVLKTIRDDNIRTMDLGG--- 703
            ....|:..: ||.|.:.:....|.:.|       |...|..:||..::|: :....|.||.|
Human   357 EHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETV-ESGAMTKDLAGCIH 420

  Fly   704 ---KAKCSE-------YTDALIKNL 718
               ..|.:|       :.|.:..||
Human   421 GLSNVKLNEHFLNTTDFLDTIKSNL 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004	11/40 (28%)
		Iso_dh	382..718	CDD:294303	89/416 (21%)
IDH2	NP_002159.2	PTZ00435	39..451	CDD:240417	96/454 (21%)
		Substrate binding. /evidence=ECO:0000250	134..140		3/5 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910