DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32026 and idh2

DIOPT Version :9

Sequence 1:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_595203.2	Gene:	idh2 / 2541260	PomBaseID:	SPBC902.05c	Length:	379	Species:	Schizosaccharomyces pombe

Alignment Length:	357	Identity:	193/357 - (54%)
Similarity:	254/357 - (71%)	Gaps:	13/357 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 KGGAGGKSG--KASGEPRVITLMPGDGIGPEISMAVIKILEAAKTPLIFEPVDVTPVLNSQGMTS 430
            |..||...|  .|:|. ..:|::.||||||||:.:|.:|.:|||.|:.:|.|.|.|:|.: |.|:
pombe    31 KAAAGTYEGVKNANGN-YTVTMIAGDGIGPEIAQSVERIFKAAKVPIEWERVKVYPILKN-GTTT 93

  Fly   431 VPEQVIESMNRTKVGLKGPLMTPVGTGFRSLNLTLRQLFNLYANIRPCRSLPGVETVYGDVDIVT 495
            :|:...||:.:.||.|||||.||:|.|..|:|||||:.|.|:||:|||.|:.|.:|.|.:|:.|.
pombe    94 IPDDAKESVRKNKVALKGPLATPIGKGHVSMNLTLRRTFGLFANVRPCVSITGYKTPYDNVNTVL 158

  Fly   496 IRENTEGEYSGIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAMKRKKVTAVAESQVMRMSDG 560
            ||||||||||||||.::.|||||||||||.||.||..|.||||....:..:|.|.::.:|||:||
pombe   159 IRENTEGEYSGIEHEVIPGVVQSIKLITRAASERVIRYAFQYARQTGKNNITVVHKATIMRMADG 223

  Fly   561 LFLRCVREMAAKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYD--MLVLPNLYGDIISDTCAGL 623
            |||.|.:|:|.:|..      |:..|..:...||.||.||..|:  ::|:|||||||:||.||||
pombe   224 LFLECAKELAPEYPD------IELREEILDNACLKIVTDPVPYNNTVMVMPNLYGDIVSDMCAGL 282

  Fly   624 IGGLGLTPSGNVGTNGAIFESVHGTAPDIAGKDLANPTALLLSSVMMLHYIGLHEHADKIEKAVL 688
            |||||||||||:|...:|||:|||||||||||.|||||||||||||||.::.|:::|.:||.|:.
pombe   283 IGGLGLTPSGNIGNQASIFEAVHGTAPDIAGKGLANPTALLLSSVMMLKHMNLNDYAKRIESAIF 347

  Fly   689 KTIRDD-NIRTMDLGGKAKCSEYTDALIKNLK 719
            .|:.:: :.||.|||||:...:||||:|..||
pombe   348 DTLANNPDARTKDLGGKSNNVQYTDAIISKLK 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	185/338 (55%)
idh2	NP_595203.2	Iso_dh	44..378	CDD:294303	186/341 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	404	1.000	Domainoid score	I98
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	412	1.000	Inparanoid score	I361
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	1	1.000	-	-		otm47211
orthoMCL	1	0.900	-	-		OOG6_100541
Panther	1	1.100	-	-	O	PTHR11835
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X402
TreeFam	1	0.960	-	-
	10	9.820