DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and LIMD1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_055055.1	Gene:	LIMD1 / 8994	HGNCID:	6612	Length:	676	Species:	Homo sapiens

Alignment Length:	667	Identity:	182/667 - (27%)
Similarity:	281/667 - (42%)	Gaps:	163/667 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QQLRELSLPKGDTGSPLVCIGHGKVA-----KLVAKISNNQNASVKRRLDIPPKPPIKYNEMPQV 65
            |.|:|.:||:|..| |:  .|.|::.     ::|..         |..:|...|||:..:  ...
Human    63 QLLQEETLPRGSRG-PV--NGGGRLGPQARWEVVGS---------KLTVDGAAKPPLAAS--TGA 113

  Fly    66 PSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFGVAD-------TQINRKTTLDNPAIL 123
            |.:...|.:.:|.|...    |:..|.::...::.|.:.|..:       :..::....::|:.|
Human   114 PGAVTTLAAGQPPYPPQ----EQRSRPYLHGTRHGSQDCGSRESLATSEMSAFHQPGPCEDPSCL 174

  Fly   124 EQQLEALAYHKLQM------EKKGL---LGVQA---------------KP--TQPLNSFTKPLSK 162
               .....|..|.:      :|.|:   :|:..               ||  ..|||.....||.
Human   175 ---THGDYYDNLSLASPKWGDKPGVSPSIGLSVGSGWPSSPGSDPPLPKPCGDHPLNHRQLSLSS 236

  Fly   163 TLSKSLIYSNLGSVRKEIETLELLTDETKISASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNE 227
            :.|..   .:||.....|              ...|:...|.:.|:.||.:    |.....|.|.
Human   237 SRSSE---GSLGGQNSGI--------------GGRSSEKPTGLWSTASSQR----VSPGLPSPNL 280

  Fly   228 KDELP-----PPPSPESAVSSSYSELRHATLE-------------FNKP-ID---YLQNNQTTNP 270
            ::..|     .|.:|..:...:.|..|...|.             .:|| :|   :.|:...:
Human   281 ENGAPAVGPVQPRTPSVSAPLALSCPRQGGLPRSNSGLGGEVSGVMSKPNVDPQPWFQDGPKS-- 343

  Fly   271 LQIYANQYAMQHDATGKSSSTYDSIYEPINPRPCVAD--TLPRESYNLHNSYVNDNNPNIS-HEY 332
               |.:..|......|...|...:: ..:.|:|...|  |.|:.|.......|....|.:| .|.
Human   344 ---YLSSSAPSSSPAGLDGSQQGAV-PGLGPKPGCTDLGTGPKLSPTSLVHPVMSTLPELSCKEG 404

  Fly   333 NISNSIEANQTLYIHGNARTTFYDVNSIHRNDKEGLKNYISIPTEPV------------------ 379
            .:..|.:        |:..:...|..|..|         :.:|.:|:
Human   405 PLGWSSD--------GSLGSVLLDSPSSPR---------VRLPCQPLVPGPELRPSAAELKLEAL 452

  Fly   380 -QELEN----------YGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDG 433
             |.||.          :|.||||:..|.|....|.||..:||..||||..|...|:||.||.::|
Human   453 TQRLEREMDAHPKADYFGACVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNG 517

  Fly   434 KPYCEYDYL-----QTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQ 493
            |.:||.|:|     |:.::|.:|...|::.||:|.||.|||.||.||:|.:.|||:.||||:.|:
Human   518 KVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENK 582

  Fly   494 NYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCY 558
            .||:.|:||..||:|..|..||:|..|.:||||||::||.:|:|||.||||||.|:.| :|..||
Human   583 IYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDE-DGHRCY 646

  Fly   559 PLDDHVLCKSCNAKRVQ 575
            ||:||:.|.||:.||::
Human   647 PLEDHLFCHSCHVKRLE 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	25/52 (48%)
		LIM2_LPP	448..507	CDD:188740	30/58 (52%)
		LIM3_LPP	508..575	CDD:188821	38/66 (58%)
LIMD1	NP_055055.1	Mediates nuclear export	54..134		21/88 (24%)
		Atrophin-1	<69..443	CDD:331285	78/438 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..163		11/64 (17%)
		Interaction with EGLN1/PHD2	186..260		15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..389		42/226 (19%)
		Interaction with RB1. /evidence=ECO:0000269\|PubMed:15542589	404..442		7/54 (13%)
		Necessary for nuclear localization	472..676		97/193 (50%)
		LIM1_Ajuba_like	472..525	CDD:188738	25/52 (48%)
		LIM2_Ajuba_like	537..589	CDD:188741	26/51 (51%)
		LIM3_Ajuba_like	597..658	CDD:188822	35/61 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810