DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zyx and AJUBA

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_116265.1	Gene:	AJUBA / 84962	HGNCID:	20250	Length:	538	Species:	Homo sapiens

Alignment Length:	205	Identity:	103/205 - (50%)
Similarity:	138/205 - (67%)	Gaps:	6/205 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 EPVQELENYGRCVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDY 441
            ||....:.:|.|:|||..:.|:|:.|.|:|.:||..||.|..|...|:.|.||:::|..|||.||
Human   327 EPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDY 391

  Fly   442 L-----QTLEKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFH 501
            |     :..|||.||...|||:||:|.||.|||.||.|:||.|.|||:.||||.:||.||:||:|
Human   392 LFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYH 456

  Fly   502 KKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLC 566
            |.:||:|..|.|||:|..|.|:.:||:::||.:|.|||.||||.:.||.| ||..|:|||.|:||
Human   457 KNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDE-EGCCCFPLDGHLLC 520

  Fly   567 KSCNAKRVQA 576
            ..|:.:|:.|
Human   521 HGCHMQRLNA 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	23/52 (44%)
		LIM2_LPP	448..507	CDD:188740	36/58 (62%)
		LIM3_LPP	508..575	CDD:188821	34/66 (52%)
AJUBA	NP_116265.1	PreLIM	1..335		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..172
		PHA03418	<18..>103	CDD:177646
		Nuclear localization signal. /evidence=ECO:0000255	280..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..315
		LIM1_Ajuba_like	338..391	CDD:188738	23/52 (44%)
		LIM2_Ajuba_like	403..455	CDD:188741	32/51 (63%)
		LIM3_Ajuba_like	463..524	CDD:188822	32/61 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810