DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and trip6

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_001922831.3	Gene:	trip6 / 792697	ZFINID:	ZDB-GENE-140106-91	Length:	572	Species:	Danio rerio

Alignment Length:	499	Identity:	187/499 - (37%)
Similarity:	249/499 - (49%)	Gaps:	133/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 NLGSVRKEIETLELLTDETKISASTYSNVNETAMDS--SHSSTQKMLSVCTNFISDNEKDELPPP 234
            |.|| .|.|.|::...|......:.        :||  ..||||::.            |.:|
Zfish   120 NRGS-EKHISTIDADIDSLTCMLAD--------LDSHPQSSSTQQLY------------DNVP-- 161

  Fly   235 PSPESAVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIY----ANQY--AMQHDATGKSSSTYD 293
                      ||  :|..::...|...:.......|..:|    .|||  |..:.:|.:....|.
Zfish   162 ----------YS--KHLPMDRYNPPSQMGAQPPGRPSMVYPPPLQNQYHPAPPYTSTPQQDYVYS 214

  Fly   294 SIYEPINPRPCVAD-------TLPR---------------------ESYNLHNSYVNDNNP---- 326
            |:::|. |:|..|.       |.||                     ::|.......:.:.|
Zfish   215 SVHKPY-PQPVPASYTTASTPTGPRFTVQVKTAQPVTYSQSGRQAEQAYTPPPPRQHPSRPPQQD 278

  Fly   327 NISHEYNISNSIEANQTLY---------IHGNART--------------------TFYDVNSIHR 362
            :|...|.     :..|..|         .||:...                    ...|..|.::
Zfish   279 HIRPHYE-----QQGQGWYPPPPPPAQEPHGDPAAYKGGSGNMAGGRASQGPPVKKSQDQVSAYQ 338

  Fly   363 NDKEGLKNYISIPTEPVQEL-----------------ENYGRCVKCNSRVLGESSGCTAMDQIYH 410
            :.|:|     |.| .|.:||                 |.:|||.:|...|||:.|||.||:|::|
Zfish   339 SSKQG-----SAP-HPEEELDRLTKKLVYDMNHPPTEEYFGRCARCGDNVLGDGSGCIAMEQVFH 397

  Fly   411 IFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLEKCSVCMEPILERILRATGKPYHPQCFTCV 475
            :.||||..|...|:|:||||||.|.|||..|:.|||:||.|.||||:|||||.||.|||:|||||
Zfish   398 VECFTCITCHARLRGQPFYALDRKSYCENCYISTLERCSKCSEPILDRILRAMGKAYHPRCFTCV 462

  Fly   476 VCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVVALDRSFHLECYK 540
            |||..|||:.||||||:|.:||.|||:||||||.||.|||||:||||||:|:||||||||:.||.
Zfish   463 VCGCCLDGVPFTVDATSQIHCIDDFHRKFAPRCSVCGQPIMPEPGQEETVRIVALDRSFHVNCYV 527

  Fly   541 CEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQALTNRMTSE 584
            ||:||||||||.|||||||||.|:|||||:|.|:|.|:.:::::
Zfish   528 CEECGLLLSSEGEGRGCYPLDGHILCKSCSAHRIQDLSAKISTD 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	29/52 (56%)
		LIM2_LPP	448..507	CDD:188740	43/58 (74%)
		LIM3_LPP	508..575	CDD:188821	52/66 (79%)
trip6	XP_001922831.3	LIM1_TRIP6	375..428	CDD:188736	29/52 (56%)
		LIM	435..494	CDD:295319	43/58 (74%)
		LIM3_Zyxin_like	495..557	CDD:188743	49/61 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5544
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001663
OrthoInspector	1	1.000	-	-		otm25637
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2600
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.000