Protein Alignment Zyx and ZYX

DIOPT Version :9

• Sequence 1: NP_652015.1
• Gene: Zyx / 317824
• FlyBaseID: FBgn0011642
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001010972.1
• Gene: ZYX / 7791
• HGNCID: 13200
• Length: 572
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 185/585 - (31%)
• Similarity: 254/585 - (43%)
• Gaps: 116/585 - (19%)

  Fly    41 QNASVKRRLDIPPKPPIKYNEMPQVPSSRQVLCSREPLYSQPLIGVEKTMRGHMPFRKYLSSEFG 105
            |.|.:.|..:|||.||..:                 ||...||.|......|      .|...|.
Human    53 QRAQMGRVGEIPPPPPEDF-----------------PLPPPPLAGDGDDAEG------ALGGAFP 94

  Fly   106 VADTQINRKTTLDNPAILEQQLEALAYHKLQMEKKGLLGVQAKPTQPLNSFTKPLSKTLSKSLIY 170
            .....|.....   ||.||:  |.........|::|      .|..|:....:|..|
Human    95 PPPPPIEESFP---PAPLEE--EIFPSPPPPPEEEG------GPEAPIPPPPQPREK-------- 140

  Fly   171 SNLGSVRKEIETL-ELLTDETKIS------ASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEK 228
              :.|:..||::| .||.|.||..      :|.|.........||.|||:.         :....
Human   141 --VSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKP---------AAGGT 194

  Fly   229 DELPPPPSPES--------AVSSSYSELRHATLEFNKPIDYLQNNQTTNPLQIYANQYAMQHDAT 285
            ..|||..||.|        |.:.|.::.........||...|.....|.|:.: ||   .|....
Human   195 APLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSL-AN---TQPRGP 255

  Fly   286 GKSSSTYDSIYEPINPR--PCVADTLPRESYNLHNSYVNDNNPNISHEYNISNSIEANQ-TLYIH 347
            ..||......:.|:.|:  |..:...|    .......:..|..:.|...:|....:.| ..:.:
Human   256 PASSPAPAPKFSPVTPKFTPVASKFSP----GAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTY 316

  Fly   348 GNAR------TTFYDVNSIHRNDKEGLKNYISIPTEP-------VQELENYGR------------ 387
            ...|      ...:.|....:|     :|.:..|..|       |:|||...:
Human   317 AQQREKPRVQEKQHPVPPPAQN-----QNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQ 376

  Fly   388 -------CVKCNSRVLGESSGCTAMDQIYHIFCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTL 445
                   |.:|:..:........|:.|::||.||||..|...|||:.||:|:|.||||..|..||
Human   377 NVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTL 441

  Fly   446 EKCSVCMEPILERILRATGKPYHPQCFTCVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCV 510
            |||:.|.|||.:|:||||||.|||.|||||||.:.|:|..|.||..|:.:|:.|:||::||||.|
Human   442 EKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSV 506

  Fly   511 CKQPIMPDPGQEETIRVVALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLCKSCNAKRVQ 575
            |.:||||:||::||:||||||::||::||||||||..||.||:..||:|||.||||:.|:..|.|
Human   507 CSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQ 571

  Fly   576  575
            Human   572  571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	22/52 (42%)
		LIM2_LPP	448..507	CDD:188740	33/58 (57%)
		LIM3_LPP	508..575	CDD:188821	42/66 (64%)
ZYX	NP_001010972.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..351		76/363 (21%)
		PAT1	<201..>365	CDD:330585	33/176 (19%)
		LIM1_Zyxin	351..437	CDD:188735	26/85 (31%)
		LIM	444..503	CDD:295319	33/58 (57%)
		LIM3_Zyxin	504..570	CDD:188819	41/65 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810