DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and Limch1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_036021493.1	Gene:	Limch1 / 77569	MGIID:	1924819	Length:	1511	Species:	Mus musculus

Alignment Length:	330	Identity:	69/330 - (20%)
Similarity:	113/330 - (34%)	Gaps:	94/330 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ELSLP--KGDTGSPLVCIGHGKVAKLVAKISNNQNA--SVKRRLDIPPKPPIKYNEMPQVPSSRQ 70
            ||..|  .|:..||      |..|.:.|.:..:::|  |.|||            ::.|  :..:
Mouse   345 ELEAPPSNGEDQSP------GDAAVVPAALPEDRDAVESQKRR------------KLEQ--AGIK 389

  Fly    71 VLCSREPLYSQPLIGVEKTMRGHMPFRK---YLSSEFGVADTQINRKTTLDNPAILEQQLEA--L 130
            |:.:.:...||.....||.....:..||   :|:.:.| .|::     :.|..|.|...||.  .
Mouse   390 VMPAAQRFASQKQSSEEKEAIRDIVLRKENPFLTHQHG-KDSE-----SEDEAACLLPDLEKDDF 448

  Fly   131 AYHKLQMEKKGLLGVQAKPTQPLNSF---------------TKPLSKTLS--KSLIYSNLGSVRK 178
            |..:.:|.       |:||..|||..               :|.|||.||  |:|.:......|:
Mouse   449 AARRAKMN-------QSKPMVPLNQLLYGPYRNKDAEKAGGSKQLSKGLSDKKNLGFKRNQGQRE 506

  Fly   179 EIETLELLTDETKISASTYSNVNETAMDSSHSSTQKMLSVCTNFISDNEKDELPP-------PPS 236
            ::.|:...|.:|:......:|..:|                    .|..||:|..       .|.
Mouse   507 DVNTMVACTVQTQKDEPLETNFRKT--------------------PDRHKDDLAQRRIQGRLTPH 551

  Fly   237 PESAVSSSYSELRHATLEFNKPIDY--------LQNNQTTNPLQIYANQYAMQHDATGKSSSTYD 293
            .|:......|.:..|.||..:.:..        .||.....|......:.|::.|...:.:..|.
Mouse   552 REAPSFIKLSGITEADLETWERLKVSGETRDGDAQNTCAPEPSPEIDTETAIRDDFASRKARAYK 616

  Fly   294 SIYEP 298
            ....|
Mouse   617 KASGP 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737
		LIM2_LPP	448..507	CDD:188740
		LIM3_LPP	508..575	CDD:188821
Limch1	XP_036021493.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:406382
		DUF4757	<739..872	CDD:406382
		GBP_C	<1225..1262	CDD:419202
		LIM	1441..1498	CDD:214528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900