DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zyx and marf1

DIOPT Version :9

Sequence 1:	NP_652015.1	Gene:	Zyx / 317824	FlyBaseID:	FBgn0011642	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_012825959.2	Gene:	marf1 / 733745	XenbaseID:	XB-GENE-990483	Length:	1682	Species:	Xenopus tropicalis

Alignment Length:	623	Identity:	119/623 - (19%)
Similarity:	209/623 - (33%)	Gaps:	169/623 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DIPPKPPIK----------YNEMPQVPSSRQV--LCSREPLYSQPLIGVEKTMRGHMPFRKYLSS 102
            |:||:.|||          ||    :|::|..  :.:|....|....|...::.|.....::.:.
Frog   486 DLPPRLPIKMQQCQTLLYVYN----LPTNRDAKSISNRLRRLSDNCGGKVMSISGTSAILRFANQ 546

  Fly   103 E--------------FGVADTQINRKT---TLDNPAILEQQLEALAYHKLQMEKKGLLGVQAKPT 150
            |              ||      ||.|   |..|..:.|.:...::..|.:..||
Frog   547 ESAERAQKRMENEDVFG------NRITVSFTPRNKEVNETKNSCVSNEKAKSPKK---------- 595

  Fly   151 QPLNSFTKPL------SKTLSKSLIYSNLGSVRK--EIETL-ELLTDETKISASTYSNVNETAMD 206
              :|..||..      |.:.:|:...|..|||.|  .:::| ||...::|.:.::....::....
Frog   596 --VNKNTKLCLSIKDDSSSNTKAASKSACGSVSKNSNVKSLKELCQMQSKSNKTSQQEKDKKRNG 658

  Fly   207 SSHSSTQKMLSVCTNFISDNEKDELPPPPSPESAVSSSYSELRHATLEFNKPIDYLQNNQTTNPL 271
            ....:..:...:|||.:....::     ...::..|.|:.:....|.:.|......|.|:.....
Frog   659 DKQGTLSQSSPLCTNQMPQTARN-----VGTDNTASKSFQKRDDTTRKSNADSQKEQKNKEDVVF 718

  Fly   272 QIYANQYAMQHDATGKSSSTYDSIYEPINPRP-------CVADTLPRESYNLHNS---YVNDNNP 326
            || :|..|.......:.:|.:.|.....:.|.       |.:.....::....||   :.|..:.
Frog   719 QI-SNPSAFSKLTESRQASPFCSSQSGWSSRSLSPSLSNCSSPIATNQTGAADNSVDPFANGADI 782

  Fly   327 NISH-EYNISNSIEANQTLY----IHG----------------------NARTTFYDVNSIHRND 364
            .|.: :|.:|.. |..|||:    .||                      |.:.....|||:||..
Frog   783 QIGNLDYRMSRK-ELQQTLHDIFSRHGKIKNVELSPHTDYQLKATVQMENLQEAICAVNSLHRYK 846

  Fly   365 KEGLKNYISIPTEPVQE---LENYGRCVKCNSRVLGESSGCT----AMDQIYH-----------I 411
            ....:..:|:.|....:   |.::|     ...:|.::..|.    ...:||.           :
Frog   847 IGSKRIQVSLATGATNKSLSLLSFG-----TVSILQDAPACCLPLFKFTEIYEKKFGHKLIVSDL 906

  Fly   412 FCFTCTDCQINLQGKPFYALDGKPYCEYDYLQTLE-----------KCSVCMEPILERILRATGK 465
            :..|.| ..|..||      :|:..|....:|..:           ..:.|...:.|.:
Frog   907 YRLTDT-VTIRDQG------NGRLVCLLPSVQARQSPMGSSQSHDGSSANCSPVVFEEL------ 958

  Fly   466 PYH-PQCFT-CVVCGKSLDGLLFTVDATNQNYCITDFHKKFAPRCCVCKQPIMPDPGQEETIRVV 528
            .|| |.|.. |  ..:...|..|..|:....:.|... |.|||:.....|.      .|.|:.::
Frog   959 EYHEPICRRHC--SNRKFSGHDFDPDSYIIPFVIISL-KTFAPQVHSLLQT------HEGTVPLL 1014

  Fly   529 ALDRSFHLECYKCEDCGLLLSSEAEGRGCYPLDDHVLC 566
            :..     :||..|...  |....||:|..||:..:.|
Frog  1015 SFP-----DCYAAEFSA--LKEVQEGQGGVPLEHLITC 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zyx	NP_652015.1	LIM1_LPP	388..441	CDD:188737	11/67 (16%)
		LIM2_LPP	448..507	CDD:188740	14/60 (23%)
		LIM3_LPP	508..575	CDD:188821	13/59 (22%)
marf1	XP_012825959.2	PIN_limkain_b1_N_like	340..462	CDD:350234
		Limkain-b1	498..583	CDD:402966	17/94 (18%)
		RRM	<502..682	CDD:223796	37/206 (18%)
		RRM2_LKAP	776..864	CDD:409701	18/88 (20%)
		LOTUS_1_Limkain_b1	865..926	CDD:193591	12/72 (17%)
		LOTUS_2_Limkain_b1	993..1063	CDD:193592	17/67 (25%)
		LOTUS_3_Limkain_b1	1089..1160	CDD:193593
		LOTUS_4_Limkain_b1	1165..1236	CDD:193594
		LOTUS_5_Limkain_b1	1249..1319	CDD:193595
		LOTUS_6_Limkain_b1	1325..1395	CDD:193596
		LOTUS_7_Limkain_b1	1401..1473	CDD:193597
		LOTUS_8_Limkain_b1	1476..1551	CDD:193598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900